Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 5/20 | 0.77 |
| ▸ | MEN1 | O00255 | 9/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | POLB | P06746 | 6/20 | 0.64 |
| ▸ | RECQL | P46063 | 6/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.64 |
| ▸ | APP | P05067 | 5/20 | 0.64 |
| ▸ | XDH | P47989 | 5/20 | 0.64 |
| ▸ | FTO | Q9C0B1 | 5/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.64 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.64 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.64 |
| ▸ | APEX1 | P27695 | 5/20 | 0.64 |
| ▸ | PIM1 | P11309 | 4/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13552041 | 0.93 | MEN1 (0.76) | POLHMEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL15197351 | 0.90 | MEN1 (0.81) | POLHMEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL824468 | 0.87 | POLH (1.00) | POLHMEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL6140182 | 0.87 | POLH (0.80) | POLHMEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL30819258 | 0.87 | POLH (0.80) | POLHMEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL13776268 | 0.86 | POLH (0.82) | POLHMEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL12636895 | 0.85 | CYP3A4 (0.74) | POLHMEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL4649105 | 0.84 | ABCB1 (0.70) | POLHMEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL9733297 | 0.83 | ABCB1 (0.76) | POLHMEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL13056253 | 0.83 | POLH (0.78) | POLHMEN1KMT2ACYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9629863-B2 | CDK5 inhibitors and therapeutic uses thereof | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-04-25 | — | — | US | disclosed |
| US-20150119348-A1 | CDK5 Inhibitors and Therapeutic Uses Thereof | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119348-A1 | CDK5 Inhibitors and Therapeutic Uses Thereof | CDK5, CDK3, CDKL1 | POLH 2889/4885MEN1 4004/4885KMT2A 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.