Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 19/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.53 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21153921 | 0.93 | FGFR4 (0.60) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL22781316 | 0.89 | FGFR4 (0.52) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL29385382 | 0.87 | FGFR4 (0.69) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL15412791 | 0.87 | FGFR4 (0.69) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL16676911 | 0.85 | FGFR4 (0.66) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL16674626 | 0.83 | FGFR4 (0.63) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21154002 | 0.83 | FGFR4 (0.60) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21153337 | 0.81 | FGFR4 (0.57) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21154059 | 0.81 | FGFR4 (0.56) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21153635 | 0.81 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3395814-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2022-04-06 | — | — | EP | disclosed |
| EP-3508482-B1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | NANJING TRANSTHERA BIOSCIENCES CO LTD (CN) | 2020-12-16 | — | — | EP | disclosed |
| EP-3508482-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | Nanjing Transthera Biosciences Co. Ltd. (CN) | 2019-07-10 | — | — | EP | disclosed |
| WO-2018040885-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | 南京药捷安康生物科技有限公司 | 2018-03-08 | — | — | WO | disclosed |
| WO-2015061572-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORPORATION (US) | 2015-04-30 | — | — | WO | disclosed |