Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 15/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.53 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 4/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21153337 | 0.92 | FGFR4 (0.57) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL22781190 | 0.91 | FGFR4 (0.56) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL21153647 | 0.89 | FGFR4 (0.54) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL19943434 | 0.88 | LCK (0.53) | FGFR4LCKKITSRCKDR | |
| SCHEMBL21153914 | 0.87 | FGFR4 (0.51) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL29385382 | 0.86 | FGFR4 (0.69) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL15412791 | 0.86 | FGFR4 (0.69) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL16683513 | 0.85 | FGFR4 (0.67) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL5489026 | 0.83 | LCK (0.55) | FGFR4LCKKITSRCKDR | |
| SCHEMBL24335995 | 0.82 | FGFR1 (0.56) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4190775-A1 | CRYSTAL FORM OF FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITOR AND PREPARATION METHOD THEREFOR | Transthera Sciences (Nanjing), Inc. (CN) | 2023-06-07 | — | — | EP | disclosed |
| EP-3395814-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2022-04-06 | — | — | EP | disclosed |
| US-20210347756-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORPORATION | 2021-11-11 | — | — | US | disclosed |
| EP-2872491-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2021-05-05 | — | — | EP | disclosed |
| US-10875837-B2 | Inhibitors of the fibroblast growth factor receptor | BLUEPRINT MEDICINES CORPORATION (US) | 2020-12-29 | — | — | US | disclosed |
| EP-3508482-B1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | NANJING TRANSTHERA BIOSCIENCES CO LTD (CN) | 2020-12-16 | — | — | EP | disclosed |
| US-10744139-B2 | Inhibitors of fibroblast growth factor receptor and use thereof | NANJING TRANSTHERA BIOSCIENCES CO. LTD. (CN) | 2020-08-18 | — | — | US | disclosed |
| US-20200108070-A2 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | NANJING TRANSTHERA BIOSCIENCES CO. LTD. (CN) | 2020-04-09 | — | — | US | disclosed |
| US-20200109127-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORPORATION (US) | 2020-04-09 | — | — | US | disclosed |
| US-20190209564-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | NANJING TRANSTHERA BIOSCIENCES CO LTD (CN) | 2019-07-11 | — | — | US | disclosed |
| EP-3508482-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | Nanjing Transthera Biosciences Co. Ltd. (CN) | 2019-07-10 | — | — | EP | disclosed |
| US-10221154-B2 | Inhibitors of the fibroblast growth factor receptor | BLUEPRINT MEDICINES CORPORATION (US) | 2019-03-05 | — | — | US | disclosed |
| WO-2018040885-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | 南京药捷安康生物科技有限公司 | 2018-03-08 | — | — | WO | disclosed |
| US-20170174652-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORPORATION | 2017-06-22 | — | — | US | disclosed |
| US-20150119405-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORPORATION (US) | 2015-04-30 | — | — | US | disclosed |
| WO-2015061572-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORPORATION (US) | 2015-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10744139-B2 | Inhibitors of fibroblast growth factor receptor and use thereof | FGFR1, FGFR2, FGFR3 | FGFR4 6/4885FGFR1 1/4885FGFR2 2/4885 |
| US-20200109127-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | FGFR4, FGFR1, FGFR2 | FGFR4 1/4885FGFR1 2/4885FGFR2 3/4885 |
| US-20210347756-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | FGFR4, FGFR1, FGFR2 | FGFR4 1/4885FGFR1 2/4885FGFR2 3/4885 |
| US-20170174652-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | FGFR4, FGFR1, FGFR2 | FGFR4 1/4885FGFR1 2/4885FGFR2 3/4885 |
| US-10875837-B2 | Inhibitors of the fibroblast growth factor receptor | FGFR4, FGFR1, FGFR2 | FGFR4 1/4885FGFR1 2/4885FGFR2 3/4885 |
| US-20200108070-A2 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | FGFR1, FGFR2, FGFR3 | FGFR4 6/4885FGFR1 1/4885FGFR2 2/4885 |
| US-20190209564-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | FGFR1, FGFR2, FGFR3 | FGFR4 6/4885FGFR1 1/4885FGFR2 2/4885 |
| US-20150119405-A1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | FGFR4, FGFR1, FGFR2 | FGFR4 1/4885FGFR1 2/4885FGFR2 3/4885 |
| US-10221154-B2 | Inhibitors of the fibroblast growth factor receptor | FGFR4, FGFR1, FGFR2 | FGFR4 1/4885FGFR1 2/4885FGFR2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.