Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.31 |
| ▸ | FEN1 | P39748 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667192 | 0.87 | MAP3K5 (0.38) | MAP3K5MCL1MAPT | |
| SCHEMBL13032461 | 0.79 | ADRA1A (0.34) | KDM4EMEN1KMT2AMAPT | |
| SCHEMBL3480383 | 0.78 | MAP3K5 (0.32) | MAP3K5MCL1MAPT | |
| SCHEMBL3483815 | 0.77 | MCL1 (0.32) | MAP3K5MCL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3480726 | 0.77 | CA2 (0.39) | — | |
| SCHEMBL16667390 | 0.70 | MAP3K5 (0.41) | MAP3K5MCL1KDM4EPKMMAPT | |
| SCHEMBL3919835 | 0.69 | MCL1 (0.36) | MAP3K5MCL1KDM4EMEN1HTT | |
| SCHEMBL4138497 | 0.69 | MCL1 (0.36) | MAP3K5MCL1KDM4EHTTMAPT | |
| SCHEMBL16667405 | 0.65 | P2RY14 (0.38) | MAP3K5MAPT | |
| SCHEMBL3480771 | 0.63 | CA2 (0.43) | KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049200-B1 | NOVEL INHIBITORS OF BETA-LACTAMASE | METHYLGENE INC (CA) | 2015-04-29 | — | — | EP | disclosed |