Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17075225 | 0.83 | BCHE (0.44) | CCKBRHTR2BHTR2CHTR2AHTR5A | |
| SCHEMBL21282546 | 0.82 | CCKBR (0.39) | CCKBRHTR2BHRH2OPRM1BCHE | |
| SCHEMBL20505796 | 0.79 | CCKBR (0.38) | CCKBRHTR2BHRH2OPRM1BCHE | |
| SCHEMBL23758472 | 0.78 | CCKBR (0.37) | CCKBRHTR2BHTR5AHRH2OPRM1 | |
| SCHEMBL28858606 | 0.77 | HTR2A (0.32) | HTR2BHTR2CHTR2A | |
| SCHEMBL16685117 | 0.77 | HTR2A (0.38) | HTR2BHTR2CHTR2A | |
| SCHEMBL13142140 | 0.77 | CCKBR (0.36) | CCKBRHTR2BHRH2OPRM1BCHE | |
| SCHEMBL24202026 | 0.76 | CCKBR (0.38) | CCKBRHTR2BHRH2OPRM1BCHE | |
| SCHEMBL12013752 | 0.76 | CCKBR (0.42) | CCKBRHTR2BHTR2CHTR2AHTR5A | |
| SCHEMBL12141050 | 0.76 | CCKBR (0.42) | CCKBRHTR2BHTR2CHTR2AHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109081800-A | Containing CF3The synthetic method of indoline and 1,2,3,4- tetrahydroisoquinoline | 昆明学院 | 2018-12-25 | — | — | CN | claimed |
| CN-109081800-B | Containing CF3Synthesis method of indoline and 1,2,3,4-tetrahydroisoquinoline | 昆明学院 | 2021-10-01 | — | — | CN | disclosed |
| CN-109081800-A | Containing CF3The synthetic method of indoline and 1,2,3,4- tetrahydroisoquinoline | 昆明学院 | 2018-12-25 | — | — | CN | disclosed |
| WO-2015066344-A1 | 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE | ARENA PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |