Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 3/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29125163 | 0.85 | CRBN (0.38) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL6534633 | 0.78 | TOP2A (0.44) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL13349250 | 0.78 | TOP2A (0.44) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL6534567 | 0.78 | TOP2A (0.44) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL6312110 | 0.76 | CRBN (0.42) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL5269923 | 0.76 | CRBN (0.45) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL11598867 | 0.76 | CRBN (0.40) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL11082931 | 0.76 | CRBN (0.40) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL10764977 | 0.76 | CRBN (0.40) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL5073235 | 0.76 | CRBN (0.40) | CRBNTOP2ATOP2BALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015065212-A1 | NOVEL N3-AMINOALKYL DERIVATIVES OF 5-ARYLIDENEHYDANTOIN, PHARMACEUTICAL COMPOSITION CONTAINING THE ABOVE AND APPLICATION THEREOF | Uniwersytet Jagielloński (PL) | 2015-05-07 | — | — | WO | disclosed |