Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP4 | P49662 | 1/20 | 0.39 |
| ▸ | CASP5 | P51878 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12198325 | 0.85 | KDM4E (0.49) | PRKAA2CASP1CASP4CASP5LIPE | |
| SCHEMBL1668538 | 0.83 | KDM4E (0.51) | PRKAA2CASP1CASP4CASP5LIPE | |
| SCHEMBL12198260 | 0.79 | KDM4E (0.48) | PRKAA2CASP1CASP4CASP5LIPE | |
| SCHEMBL1669073 | 0.77 | PPARD (0.39) | CASP1CASP4CASP5LMNAKDM4E | |
| SCHEMBL12224859 | 0.77 | SMN1; SMN2 (0.46) | PRKAA2LIPESMN1; SMN2LMNAPRKAB2 | |
| SCHEMBL12198328 | 0.76 | KDM4E (0.42) | PRKAA2LIPEKDM4EALDH1A1PRKAB2 | |
| SCHEMBL1668769 | 0.75 | PRKAA2 (0.40) | PRKAA2SMN1; SMN2PPARACHRM4DRD4 | |
| SCHEMBL1668515 | 0.73 | ACACB (0.41) | — | |
| SCHEMBL1668706 | 0.73 | KDM4E (0.45) | PRKAA2LIPEKDM4EALDH1A1PRKAB2 | |
| SCHEMBL13894648 | 0.71 | LIPE (0.43) | PRKAA2LIPEKDM4EALDH1A1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486033-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044001-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-04-14 | — | — | WO | disclosed |