Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP4 | P49662 | 1/20 | 0.36 |
| ▸ | CASP5 | P51878 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12198370 | 0.85 | ALDH1A1 (0.51) | PPARDPPARAKDM4EALDH1A1CASP1 | |
| SCHEMBL1668235 | 0.83 | KDM4E (0.53) | PPARDPPARAKDM4EALDH1A1KDM4C | |
| SCHEMBL1670840 | 0.80 | TEAD1 (0.38) | KDM4EALDH1A1KCNH2GPR119 | |
| SCHEMBL1668614 | 0.77 | PRKAA2 (0.39) | PPARDPPARAKDM4EALDH1A1CASP1 | |
| SCHEMBL12198383 | 0.75 | KDM4E (0.49) | PPARDPPARAKDM4EALDH1A1CASP1 | |
| SCHEMBL12198375 | 0.74 | KDM4E (0.43) | PPARDPPARAKDM4EALDH1A1CASP1 | |
| SCHEMBL1668529 | 0.74 | KDM4E (0.51) | PPARDPPARAKDM4EALDH1A1KDM4C | |
| SCHEMBL1668670 | 0.72 | HTR2C (0.35) | KDM4EALDH1A1 | |
| SCHEMBL1668310 | 0.72 | KDM4E (0.46) | PPARDPPARAKDM4EALDH1A1NR1H2 | |
| SCHEMBL1668306 | 0.70 | KMT2A (0.43) | SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486033-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044001-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-04-14 | — | — | WO | disclosed |