Sugi Predict

Sugi Predict / Compounds / Sulfotep

Sulfotep

Sulfotep

SCHEMBL1668626

CCOP(=S)(OCC)OP(=S)(OCC)OCC.N

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 5/20 0.44
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ TSHR P16473 7/20 0.38
▸ TP53 P04637 2/20 0.35
▸ ALDH1A1 P00352 7/20 0.34
▸ HSD17B10 Q99714 5/20 0.34
▸ CYP3A4 P08684 4/20 0.34
▸ MAPT P10636 3/20 0.34
▸ MAPK1 P28482 2/20 0.34
▸ ALOX15 P16050 1/20 0.34
▸ ALOX12 P18054 1/20 0.34
▸ ATM Q13315 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ KDM4E B2RXH2 2/20 0.33
▸ POLB P06746 1/20 0.33
▸ PPARD Q03181 1/20 0.33
▸ GAA P10253 1/20 0.32
▸ ACHE P22303 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sulfotep SCHEMBL8191946 0.97 TDP1 (0.46) TDP1MEN1KMT2ATSHRTP53
Sulfotep SCHEMBL35637 0.97 TDP1 (0.46) TDP1MEN1KMT2ATSHRTP53
Sulfotep SCHEMBL19510253 0.94 TDP1 (0.44) TDP1MEN1KMT2ATSHRTP53
Sulfotep SCHEMBL6676271 0.94 TDP1 (0.44) TDP1MEN1KMT2ATSHRTP53
Sulfotep SCHEMBL8336123 0.94 TDP1 (0.44) TDP1MEN1KMT2ATSHRTP53
Sulfotep SCHEMBL10606468 0.94 TDP1 (0.44) TDP1MEN1KMT2ATSHRTP53
Sulfotep SCHEMBL7004800 0.94 TDP1 (0.44) TDP1MEN1KMT2ATSHRTP53
Sulfotep SCHEMBL21060526 0.94 TDP1 (0.44) TDP1MEN1KMT2ATSHRTP53
Sulfotep SCHEMBL22721240 0.94 TSHR (0.45) TDP1MEN1KMT2ATSHRTP53
Sulfotep SCHEMBL10621503 0.94 TDP1 (0.44) TDP1MEN1KMT2ATSHRTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120230976-A1 ROTHIA SPECIES GLUTAMINE ENDOPEPTIDASES AND USE THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2012-09-13 — — US disclosed
WO-2011044365-A1 ROTHIA SPECIES GLUTAMINE ENDOPEPTIDASES AND USE THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2011-04-14 — — WO disclosed
EP-1451164-A2 AMIDE DERIVATIVES HAVING IMPROVED SOLUBILITY PHARMACIA & UPJOHN COMPANY (US) 2004-09-01 — — EP disclosed
WO-2003006440-A2 AMIDE-CONTAINING COMPOUND HAVING IMPROVED SOLUBILITY AND METHOD OF IMPROVING THE SOLUBILITY OF AN AMIDE-CONTAINING COMPOUND PHARMACIA & UPJOHN COMPANY (US) 2003-01-23 — — WO disclosed
EP-1133493-A1 OXAZOLIDINONE ANTIBACTERIAL AGENTS HAVING A THIOCARBONYL FUNCTIONALITY PHARMACIA & UPJOHN COMPANY (US) 2001-09-19 — — EP disclosed
WO-2000032599-A1 OXAZOLIDINONE ANTIBACTERIAL AGENTS HAVING A THIOCARBONYL FUNCTIONALITY PHARMACIA & UPJOHN COMPANY (US) 2000-06-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120230976-A1 ROTHIA SPECIES GLUTAMINE ENDOPEPTIDASES AND USE THEREOF GLUL, DNPEP, ENPEP TDP1 2279/4885MEN1 3594/4885KMT2A 1442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.