Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16685978 | 0.82 | KDM4E (0.50) | HPGDKDM4ENCF1ALDH1A1LMNA | |
| SCHEMBL16696238 | 0.82 | HPGD (0.42) | HPGDTMEM97KDM4ESMN1; SMN2TMIGD3 | |
| SCHEMBL16696227 | 0.73 | HPGD (0.64) | HPGDKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL16696186 | 0.70 | HPGD (0.34) | HPGDKDM4ESMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL16686183 | 0.66 | L3MBTL1 (0.49) | KDM4ESMN1; SMN2RAB9ANCF1ALDH1A1 | |
| SCHEMBL16685810 | 0.64 | HPGD (0.58) | HPGDKDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL30968891 | 0.64 | HPGD (0.58) | HPGDKDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL26666782 | 0.60 | KMT2A (0.43) | KDM4ESMN1; SMN2RAB9ATHRBLMNA | |
| SCHEMBL5520884 | 0.58 | NCF1 (0.43) | HPGDKDM4ESMN1; SMN2NCF1ALDH1A1 | |
| SCHEMBL31045351 | 0.58 | USP2 (0.36) | HPGDKDM4ESMN1; SMN2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3267995-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | Case Western Reserve University (US) | 2018-01-17 | — | — | EP | disclosed |
| WO-2016144958-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-09-15 | — | — | WO | disclosed |
| EP-3057973-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | Case Western Reserve University (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015065716-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2015-05-07 | — | — | WO | disclosed |