Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16696294 | 0.74 | L3MBTL1 (0.66) | L3MBTL1HSD17B10MAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL16685781 | 0.71 | CYP2D6 (0.39) | L3MBTL1HSD17B10MAPK1HTR2CKMT2A | |
| SCHEMBL18072404 | 0.68 | L3MBTL1 (0.66) | L3MBTL1HSD17B10MAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL31221719 | 0.68 | CAMKK1 (0.38) | L3MBTL1HSD17B10MAPK1HTR2CALDH1A1 | |
| SCHEMBL26489853 | 0.68 | ATR (0.47) | — | |
| SCHEMBL32686267 | 0.67 | HTR2C (0.36) | L3MBTL1HSD17B10MAPK1SMN1; SMN2HTR2C | |
| SCHEMBL30611850 | 0.67 | NCF1 (0.39) | L3MBTL1HSD17B10KDM4ESMN1; SMN2NCF1 | |
| SCHEMBL26110488 | 0.67 | NCF1 (0.39) | L3MBTL1HSD17B10KDM4ESMN1; SMN2NCF1 | |
| SCHEMBL16686267 | 0.66 | HPGD (0.34) | KDM4ESMN1; SMN2NCF1ALDH1A1LMNA | |
| SCHEMBL4696003 | 0.65 | CYP2D6 (0.34) | L3MBTL1HSD17B10MAPK1SMN1; SMN2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3267995-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | Case Western Reserve University (US) | 2018-01-17 | — | — | EP | disclosed |
| WO-2016144958-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-09-15 | — | — | WO | disclosed |
| EP-3057973-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | Case Western Reserve University (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015065716-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2015-05-07 | — | — | WO | disclosed |