Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12679100 | 1.00 | MAPT (0.50) | MAPTPOLBLMNAMAPK1MEN1 | |
| SCHEMBL17236156 | 1.00 | MAPT (0.50) | MAPTPOLBLMNAMAPK1MEN1 | |
| SCHEMBL17231867 | 0.92 | MAPT (0.51) | MAPTPOLBLMNAMAPK1MEN1 | |
| SCHEMBL14616550 | 0.92 | MAPT (0.53) | MAPTPOLBLMNAMAPK1MEN1 | |
| SCHEMBL16692028 | 0.87 | MAPT (0.53) | MAPTPOLBLMNAMAPK1MEN1 | |
| SCHEMBL22787195 | 0.85 | LMNA (0.39) | POLBLMNAMAPK1KMT2AALDH1A1 | |
| SCHEMBL21098733 | 0.85 | LMNA (0.48) | MAPTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL22787130 | 0.85 | LMNA (0.39) | POLBLMNAMAPK1KMT2AALDH1A1 | |
| SCHEMBL29526638 | 0.85 | LMNA (0.39) | POLBLMNAMAPK1KMT2AALDH1A1 | |
| SCHEMBL22773527 | 0.85 | KMT2A (0.41) | MAPTPOLBLMNAMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108047287-B | Intermediates and methods for the synthesis of calicheamicin derivatives | 辉瑞大药厂 | 2021-04-27 | — | — | CN | disclosed |
| US-10508081-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | PFIZER INC. (US) | 2019-12-17 | — | — | US | disclosed |
| US-20180134656-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180133337-A1 | CALICHEAMICIN CONSTRUCTS AND METHODS OF USE | ABBVIE STEMCENTRX LLC (US) | 2018-05-17 | — | — | US | disclosed |
| US-9902691-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | PFIZER INC. (US) | 2018-02-27 | — | — | US | disclosed |
| EP-3066074-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | Pfizer Inc. (US) | 2016-09-14 | — | — | EP | disclosed |
| US-20160251389-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2016-09-01 | — | — | US | disclosed |
| WO-2015063680-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2015-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10508081-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | CALR, CALD1, CYCS | MAPT 4253/4885POLB 1877/4885LMNA 1521/4885 |
| US-20160251389-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | CALR, CALD1, CYCS | MAPT 4253/4885POLB 1877/4885LMNA 1521/4885 |
| US-20180134656-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | CALR, CALD1, CYCS | MAPT 4253/4885POLB 1877/4885LMNA 1521/4885 |
| US-20180133337-A1 | CALICHEAMICIN CONSTRUCTS AND METHODS OF USE | CALD1, CALR, CLSPN | MAPT 2033/4885POLB 1774/4885LMNA 2630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.