Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17231867 | 0.88 | MAPT (0.51) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL16687019 | 0.87 | MAPT (0.50) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL17236156 | 0.87 | MAPT (0.50) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL12679100 | 0.87 | MAPT (0.50) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL22815762 | 0.79 | MAPT (0.43) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL21052063 | 0.79 | MAPT (0.58) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL21052062 | 0.79 | MAPT (0.58) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL22214478 | 0.79 | MAPT (0.54) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL16692026 | 0.79 | MEN1 (0.45) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL17231868 | 0.79 | MAPT (0.42) | MAPTMEN1KMT2APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9381205-B2 | Anti-EFNA4 antibody-drug conjugates | PFIZER, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150125472-A1 | ANTI-EFNA4 ANTIBODY-DRUG CONJUGATES | STEM CENTRX, INC. (US) | 2015-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150125472-A1 | ANTI-EFNA4 ANTIBODY-DRUG CONJUGATES | EFNA1, ACTN4, AFF4 | MAPT 2270/4885MEN1 3636/4885KMT2A 2007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.