Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835669 | 0.86 | CCNE1 (0.52) | NPC1RAB9ASMN1; SMN2MAPK1KDM4E | |
| SCHEMBL16688458 | 0.81 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2MAPK1KDM4E | |
| SCHEMBL16688465 | 0.80 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2MAPK1KDM4E | |
| SCHEMBL6833294 | 0.77 | RAB9A (0.66) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL6839243 | 0.77 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL6839379 | 0.76 | MAPT (0.63) | NPC1RAB9ASMN1; SMN2MAPK1KDM4E | |
| SCHEMBL5584871 | 0.76 | KMT2A (0.72) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL6837523 | 0.75 | MAPT (0.67) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL23143737 | 0.75 | LMNA (0.54) | NPC1RAB9ASMN1; SMN2MAPK1KDM4E | |
| SCHEMBL6839269 | 0.74 | LMNA (0.60) | NPC1RAB9ASMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150126507-A1 | COMPOUNDS TO TREAT HEARING LOSS | US ARMY, SECRETARY OF THE ARMY | 2015-05-07 | — | — | US | disclosed |
| US-20150126507-A1 | COMPOUNDS TO TREAT HEARING LOSS | US ARMY, SECRETARY OF THE ARMY | 2015-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126507-A1 | COMPOUNDS TO TREAT HEARING LOSS | NGF, DCX, OTC | NPC1 701/4885RAB9A 4077/4885SMN1; SMN2 2048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.