Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12198415 | 0.87 | GPR119 (0.51) | GPR119MAPK1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL1669016 | 0.85 | GPR119 (0.56) | GPR119MAPK1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL1668925 | 0.81 | LMNA (0.44) | GPR119MAPK1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL1670715 | 0.79 | GPR119 (0.41) | GPR119MAPK1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL1668613 | 0.73 | GPR119 (0.52) | GPR119MAPK1L3MBTL1LMNAHTT | |
| SCHEMBL1671302 | 0.73 | GPR119 (0.62) | GPR119ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL12198414 | 0.73 | GPR119 (0.51) | GPR119MAPK1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL1669279 | 0.72 | GPR119 (0.38) | GPR119MAPK1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL1668836 | 0.72 | GPR119 (0.56) | GPR119MAPK1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL12198416 | 0.70 | GPR119 (0.47) | GPR119ALDH1A1LMNAHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486033-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044001-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-04-14 | — | — | WO | disclosed |