Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670715 | 0.93 | GPR119 (0.41) | GPR119HTTALDH1A1NPC1RAB9A | |
| SCHEMBL12198396 | 0.87 | GPR119 (0.37) | GPR119POLBHTTALDH1A1NPC1 | |
| SCHEMBL1669280 | 0.85 | GPR119 (0.42) | GPR119POLBHTTALDH1A1NPC1 | |
| SCHEMBL12198391 | 0.80 | POLB (0.36) | GPR119POLBALDH1A1NPC1RAB9A | |
| SCHEMBL1668930 | 0.79 | DRD2 (0.31) | — | |
| SCHEMBL1669001 | 0.79 | GPR119 (0.41) | GPR119POLBHTTALDH1A1NPC1 | |
| SCHEMBL1668891 | 0.79 | GPR119 (0.48) | GPR119POLBHTTALDH1A1NPC1 | |
| SCHEMBL1668356 | 0.78 | GPR119 (0.46) | GPR119HTTLMNAMAPK1L3MBTL1 | |
| SCHEMBL1668306 | 0.75 | KMT2A (0.43) | — | |
| SCHEMBL1668925 | 0.73 | LMNA (0.44) | GPR119HTTALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486033-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2012-08-15 | — | — | EP | claimed |
| WO-2011044001-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-04-14 | — | — | WO | claimed |