Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.32 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24629242 | 0.82 | MAPT (0.38) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL26535566 | 0.82 | L3MBTL1 (0.36) | TDP1L3MBTL1KMT2ANOD1POLB | |
| SCHEMBL21516155 | 0.82 | TDP1 (0.36) | ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL8254919 | 0.81 | MAPT (0.43) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL24983988 | 0.81 | MAPT (0.43) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL25603577 | 0.80 | L3MBTL1 (0.35) | L3MBTL1FOLH1KMT2ANOD1POLB | |
| SCHEMBL20122050 | 0.80 | NOD1 (0.54) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL14557465 | 0.79 | FOLH1 (0.52) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL17718255 | 0.79 | FOLH1 (0.52) | MAPTKDM4ETHRBALOX15NFKB1 | |
| SCHEMBL16250367 | 0.79 | KDM4E (0.42) | MAPTKDM4ETHRBALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012046062-A1 | USE OF PRODRUGS TO AVOID GI MEDIATED ADVERSE EVENTS | SHIRE, LLC (US) | 2012-04-12 | — | — | WO | disclosed |