Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 12/20 | 0.60 |
| ▸ | IP6K3 | Q96PC2 | 4/20 | 0.58 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886644 | 0.93 | IP6K1 (0.59) | IP6K1IP6K3IP6K2CHRNA7PARP1 | |
| SCHEMBL1672235 | 0.80 | CHRNA7 (0.45) | IP6K1CHRNA7 | |
| SCHEMBL1669111 | 0.79 | HPGD (0.46) | CHRNA7PARP1 | |
| SCHEMBL8871369 | 0.76 | IP6K1 (1.00) | IP6K1IP6K3IP6K2 | |
| SCHEMBL1670541 | 0.76 | CHRNA7 (0.44) | CHRNA7PARP1 | |
| SCHEMBL8976326 | 0.74 | IP6K1 (1.00) | IP6K1IP6K3IP6K2CHEK1PIM1 | |
| SCHEMBL1669269 | 0.74 | TNKS (0.44) | CHRNA7PARP1 | |
| SCHEMBL6886724 | 0.74 | ACVR1 (0.49) | CHRNA7 | |
| SCHEMBL6886458 | 0.71 | CHRNA7 (0.50) | IP6K1CHRNA7 | |
| SCHEMBL6888091 | 0.70 | TNKS (0.51) | CHRNA7PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488520-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | MSD Oss B.V. (NL) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045258-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | N.V. ORGANON (NL) | 2011-04-21 | — | — | WO | disclosed |