EFNA1

Ephrin-A1 (EPH-related receptor tyrosine kina · P20827 · EFNA1 on Sugi Atlas →

5,269 patent compounds predicted against EFNA1, 4,455 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Ursocholanic Acid (SCHEMBL190519)	1.00	1/20
Ursocholanic Acid (SCHEMBL190520)	1.00	1/20
Ursocholanic Acid (SCHEMBL1688735)	1.00	1/20
Ursocholanic Acid (SCHEMBL4355368)	1.00	1/20
Lithocholic Acid (SCHEMBL288628)	0.86	1/20
SCHEMBL4740095	0.83	1/20
SCHEMBL1656460	0.82	1/20
SCHEMBL4008010	0.82	1/20
SCHEMBL3899452	0.79	1/20
SCHEMBL4326984	0.79	1/20
SCHEMBL4326989	0.79	1/20
SCHEMBL4998834	0.79	1/20
SCHEMBL288629	0.79	1/20
Ursodiol (SCHEMBL288121)	0.77	1/20
Chenodiol (SCHEMBL288703)	0.77	1/20
SCHEMBL1688731	0.75	1/20
SCHEMBL3124375	0.74	1/20
SCHEMBL381612	0.74	1/20
SCHEMBL4021386	0.74	1/20
SCHEMBL4751618	0.74	1/20

Clinical trials — most relevant to EFNA1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of Pre-operative Electrical Stimulation on Peripheral Nerve Regeneration.	PHASE2/PHASE3	COMPLETED
CONTROL Walking Study	PHASE1	COMPLETED
Extension Study of XLHED-Affected Male Subjects Treated With EDI200 in Protocol ECP-002	nan	UNKNOWN
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy.	nan	UNKNOWN
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins.	nan	UNKNOWN
Enlarged Vestibular Aqueduct Registry	nan	COMPLETED
The Role of Gene Changes in Brain Tumor Formation and Growth	nan	COMPLETED
Impact of Elastin Mediated Vascular Stiffness on End Organs	nan	COMPLETED
The Association Between Executive Functions and Candidate Genes of Dopaminergic and Noradrenergic Systems in Attention Deficit Hyperactivity Disorder (ADHD)	nan	COMPLETED
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury	nan	UNKNOWN
Young Pectus Excavatum Patients and Genetic Defects	nan	COMPLETED
Baker Gordon Syndrome Natural History Study	nan	RECRUITING
Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers	nan	COMPLETED
Identification of New Genes Implicated in Rare Neurosensory Diseases by Whole Exome Sequencing	nan	UNKNOWN
The Roles of Neutrophil Elastase in Lung Cancer	nan	UNKNOWN
Speech and Short-term Memory Functions in Dyslexia: a Combined MEG and EEG Study	nan	UNKNOWN
Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank	nan	COMPLETED
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
CADASIL Disease Discovery	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Genetics of Neonatal Encephalopathy and Related Disorders	nan	RECRUITING
Family Blood Pressure Program - GENOA	nan	COMPLETED
Mapping Disease Pathways for Biliary Atresia	nan	RECRUITING
Identifying Genes That May Increase the Risk for Heart Disease in African Americans	nan	COMPLETED
Audio-vestibular Evaluation of Children and Young Adults With Osteogenesis Imperfecta	nan	RECRUITING
Intra-cortical Inhibition and Cognitive Deficits in Schizophrenia	nan	UNKNOWN
Natural History of Autosomal Dominant Hearing Loss	nan	RECRUITING
Endocan Predictive Value in Postcardiac Surgery Acute Respiratory Failure.	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a EFNA1 binder may also engage these)

Protein	Name	Similarity
P97553	—	1.000	P97553 →
Q06AS9	—	0.996	Q06AS9 →
P52793	—	0.991	P52793 →
Q3ZC64	—	0.973	Q3ZC64 →
Q8JG54	—	0.945	Q8JG54 →
O73612	—	0.942	O73612 →
P98172	—	0.942	P98172 →
O00292	—	0.941	O00292 →
Q6IEE7	—	0.940	Q6IEE7 →
Q6ZRP7	—	0.940	Q6ZRP7 →
Q6NW40	—	0.940	Q6NW40 →
O75610	—	0.940	O75610 →
P52800	—	0.939	P52800 →
P52799	—	0.939	P52799 →
P57785	—	0.939	P57785 →
P52795	—	0.939	P52795 →
P52796	—	0.939	P52796 →
Q7TQ33	—	0.939	Q7TQ33 →
Q6NZ13	—	0.937	Q6NZ13 →
Q5JXM2	—	0.936	Q5JXM2 →
Q9I946	—	0.935	Q9I946 →
P41271	—	0.935	P41271 →
Q3TMX7	—	0.935	Q3TMX7 →
Q64280	—	0.934	Q64280 →
E5RIL1	—	0.934	E5RIL1 →
O70326	—	0.933	O70326 →
A6QM06	—	0.933	A6QM06 →
Q96B86	—	0.932	Q96B86 →
A2RRU4	—	0.932	A2RRU4 →
B0FP48	—	0.932	B0FP48 →