Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | DVL1 | O14640 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613781 | 0.85 | PIM1 (0.53) | PIM1PPARGALDH1A1DVL1ENPP2 | |
| SCHEMBL1614757 | 0.83 | ENPP2 (0.61) | PPARGALDH1A1ENPP2MEN1KMT2A | |
| SCHEMBL1612918 | 0.73 | PPARG (0.50) | PIM1PPARGALDH1A1ENPP2MEN1 | |
| SCHEMBL1614334 | 0.73 | ENPP2 (0.54) | PIM1PPARGALDH1A1ENPP2MEN1 | |
| SCHEMBL1614287 | 0.72 | MCL1 (0.47) | PPARGALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL2548401 | 0.72 | PIM1 (1.00) | PIM1PPARGALDH1A1ENPP2MEN1 | |
| SCHEMBL2548399 | 0.72 | PIM1 (1.00) | PIM1PPARGALDH1A1ENPP2MEN1 | |
| SCHEMBL1613879 | 0.70 | SLC2A1 (0.57) | PPARGALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL5462147 | 0.69 | MEN1 (0.58) | ALDH1A1ENPP2MEN1KMT2APTPN1 | |
| SCHEMBL5462143 | 0.69 | MEN1 (0.58) | ALDH1A1ENPP2MEN1KMT2APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488027-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | The Ohio State University Research Foundation (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011044548-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | WO | disclosed |