Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613879 | 0.86 | SLC2A1 (0.57) | MCL1SLC2A1CISD1ALDH1A1KDM4E | |
| SCHEMBL1614903 | 0.82 | SLC2A1 (0.51) | MCL1SLC2A1CISD1ALDH1A1KDM4E | |
| SCHEMBL1612918 | 0.79 | PPARG (0.50) | MCL1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL12712457 | 0.78 | COMT (0.53) | SLC2A1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL12712459 | 0.77 | CISD1 (0.46) | MCL1SLC2A1CISD1ALDH1A1KDM4E | |
| SCHEMBL1614757 | 0.76 | ENPP2 (0.61) | ALDH1A1MEN1KMT2APOLBPPARG | |
| SCHEMBL12712441 | 0.76 | SLC2A1 (0.57) | SLC2A1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1614944 | 0.75 | AURKA (0.50) | MCL1CISD1ALDH1A1LMNAHTT | |
| SCHEMBL1615131 | 0.74 | SLC2A1 (0.61) | SLC2A1COMTPPARGAKR1B1 | |
| SCHEMBL1614983 | 0.74 | HPGD (0.46) | CISD1ALDH1A1KMT2AHTTCOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488027-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | The Ohio State University Research Foundation (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011044548-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | WO | claimed |
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | US | claimed |
| US-8383656-B2 | Thiazolidinedione energy restriction-mimetic agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383656-B2 | Thiazolidinedione energy restriction-mimetic agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383656-B2 | Thiazolidinedione energy restriction-mimetic agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-02-26 | — | — | US | disclosed |
| EP-2488027-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | The Ohio State University Research Foundation (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011044548-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | WO | disclosed |
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | PCK2, AK2, SIRT6 | MCL1 996/4885SLC2A1 76/4885CISD1 2625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.