Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993286 | 0.82 | BACE1 (0.41) | BACE1MAPTSMN1; SMN2GAA | |
| SCHEMBL16197279 | 0.81 | MAPT (0.37) | BACE1MAPTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL9939055 | 0.80 | RECQL (0.50) | MAPTSMN1; SMN2 | |
| SCHEMBL1403152 | 0.79 | BACE1 (0.40) | BACE1MAPTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL1403176 | 0.79 | BACE1 (0.40) | BACE1MAPTSMN1; SMN2GAA | |
| SCHEMBL7992161 | 0.78 | BACE1 (0.39) | BACE1MAPTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL695478 | 0.76 | BACE1 (0.38) | BACE1 | |
| SCHEMBL16701732 | 0.75 | GABRA1 (0.38) | BACE1 | |
| SCHEMBL14698626 | 0.75 | MAPT (0.32) | BACE1MAPTSMN1; SMN2 | |
| SCHEMBL15141075 | 0.73 | LMNA (0.36) | MAPTSMN1; SMN2GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3215505-A1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | Bayer Pharma Aktiengesellschaft (DE) | 2017-09-13 | — | — | EP | disclosed |
| EP-3066100-A1 | (AZA)PYRIDOPYRAZOLOPYRIMIDINONES AND INDAZOLOPYRIMIDINONES AS INHIBITORS OF FIBRINOLYSIS | Bayer Pharma Aktiengesellschaft (DE) | 2016-09-14 | — | — | EP | disclosed |
| WO-2016071216-A1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-12 | — | — | WO | disclosed |
| WO-2015067549-A1 | (AZA)PYRIDOPYRAZOLOPYRIMIDINONES AND INDAZOLOPYRIMIDINONES AS INHIBITORS OF FIBRINOLYSIS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-05-14 | — | — | WO | disclosed |