Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18154007 | 0.80 | ATM (0.43) | TDP1ATMCASP6ALDH1A1TSHR | |
| SCHEMBL8799973 | 0.79 | CYP1A2 (0.39) | TDP1ALDH1A1TSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL8799963 | 0.79 | CYP1A2 (0.39) | TDP1ALDH1A1TSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL8618765 | 0.78 | SMN1; SMN2 (0.50) | TDP1ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL8952221 | 0.78 | SMN1; SMN2 (0.50) | TDP1ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL18147353 | 0.76 | ATM (0.50) | TDP1ATMCASP6ALDH1A1TSHR | |
| SCHEMBL18147351 | 0.76 | ATM (0.50) | TDP1ATMCASP6ALDH1A1TSHR | |
| SCHEMBL7900446 | 0.74 | ALDH1A1 (0.59) | TDP1ATMALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8618010 | 0.71 | ALDH1A1 (0.44) | ALDH1A1TSHRSMN1; SMN2CYP1A2MAPT | |
| SCHEMBL14180498 | 0.70 | TDP1 (0.55) | TDP1ATMALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066098-A1 | SUBSTITUTED URACILS AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015067630-A1 | SUBSTITUTED URACILS AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-05-14 | — | — | WO | disclosed |