Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.46 |
| ▸ | TTR | P02766 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040026 | 0.86 | MAPT (0.46) | MAPTLMNAMEN1KMT2ATDP1 | |
| SCHEMBL11007373 | 0.83 | GPR35 (0.52) | MAPTLMNAMEN1KMT2ATDP1 | |
| SCHEMBL11330105 | 0.81 | GPR35 (0.50) | MAPTLMNAMEN1KMT2ATDP1 | |
| SCHEMBL17744715 | 0.81 | GPR35 (0.50) | MAPTLMNAMEN1KMT2ATDP1 | |
| SCHEMBL3840638 | 0.81 | TTR (0.44) | MAPTMEN1KMT2ATDP1GPR35 | |
| SCHEMBL3640209 | 0.81 | ERN1 (0.59) | MAPTLMNAMEN1KMT2ATDP1 | |
| SCHEMBL6010796 | 0.78 | GPR35 (0.63) | MAPTLMNAMEN1KMT2ATDP1 | |
| SCHEMBL17744242 | 0.77 | LMNA (0.47) | MAPTLMNAMEN1KMT2ATDP1 | |
| SCHEMBL535349 | 0.77 | MAPK1 (0.50) | MAPTLMNAMEN1KMT2ATDP1 | |
| SCHEMBL405093 | 0.77 | TSHR (0.55) | MAPTLMNAMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015069110-A1 | MULTIPLE D2 A(NTA)GONISTS/H3 ANTAGONISTS FOR TREATMENT OF CNS-RELATED DISORDERS | AAPA B.V. (NL) | 2015-05-14 | — | — | WO | disclosed |