Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 9/20 | 0.63 |
| ▸ | TTR | P02766 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4172077 | 0.89 | TTR (0.67) | GPR35TTRMAPTMEN1KMT2A | |
| Niclofolan SCHEMBL1498232 | 0.89 | GPR35 (0.57) | GPR35TTRMAPTMEN1KMT2A | |
| Niclofolan SCHEMBL29385615 | 0.89 | GPR35 (0.57) | GPR35TTRMAPTMEN1KMT2A | |
| SCHEMBL310420 | 0.89 | GPR35 (0.69) | GPR35TTRMAPTMEN1KMT2A | |
| SCHEMBL18304977 | 0.86 | TTR (0.54) | GPR35TTRMAPTMEN1KMT2A | |
| SCHEMBL4969056 | 0.86 | GPR35 (0.65) | GPR35TTRMAPTMEN1KMT2A | |
| SCHEMBL11622992 | 0.86 | GPR35 (0.65) | GPR35TTRMAPTMEN1KMT2A | |
| SCHEMBL28045327 | 0.86 | GPR35 (0.53) | GPR35TTRMAPTMEN1KMT2A | |
| SCHEMBL1248770 | 0.86 | GPR35 (0.65) | GPR35TTRMAPTMEN1KMT2A | |
| SCHEMBL3355632 | 0.86 | GPR35 (0.53) | GPR35TTRMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4474646-A | DINITROPHENOIS | THE SHERWIN-WILLIAMS COMPANY (US) | 1984-10-02 | — | — | US | claimed |
| US-8778876-B2 | Small-molecule inhibitors of Dengue and West Nile virus proteases | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778876-B2 | Small-molecule inhibitors of Dengue and West Nile virus proteases | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130035284-A1 | SMALL-MOLECULE INHIBITORS OF DENGUE AND WEST NILE VIRUS PROTEASES | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-02-07 | — | — | US | disclosed |
| US-20130035284-A1 | SMALL-MOLECULE INHIBITORS OF DENGUE AND WEST NILE VIRUS PROTEASES | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-02-07 | — | — | US | disclosed |
| US-7045516-B1 | Benzoxazole derivatives and drugs containing the same as the active ingredient | KOICHI SHUDO (JP) | 2006-05-16 | — | — | US | disclosed |
| EP-1134220-B1 | BENZOXAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | SHUDO KOICHI (JP) | 2004-08-18 | — | — | EP | disclosed |
| EP-1134220-A1 | BENZOXAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | MEIJI SEIKA KAISHA LTD. (JP) | 2001-09-19 | — | — | EP | disclosed |
| EP-0352489-B1 | USE OF 2,6-DINITROPHENOL DERIVATIVES IN HAIR DYEING COMPOSITIONS | Wella Aktiengesellschaft (DE) | 1992-06-17 | — | — | EP | disclosed |
| US-4975093-A | Hair dyeing compositions containing 2,6-dinitro-phenol-derivatives | WELLA AKTIENGESELLSCHAFT (DE) | 1990-12-04 | — | — | US | disclosed |
| EP-0283315-A1 | Method for recovery of polymerization inhibitor | NIPPON STEEL CHEMICAL CO., LTD. (JP) | 1988-09-21 | — | — | EP | disclosed |
| EP-0124084-B1 | PROCESS FOR THE PREPARATION OF 6-CHLORO-2,4-DINITROPHENOL | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-09-07 | — | — | EP | disclosed |
| EP-0226064-A2 | Improved dehydrogenation process for production of styrene from ethylbenzene comprising low temperature heat recovery and modification of the ethyl-benzene-steam feed therewith | Lummus Crest, Inc. (US) | 1987-06-24 | — | — | EP | disclosed |
| US-4628136-A | Dehydrogenation process for production of styrene from ethylbenzene comprising low temperature heat recovery and modification of the ethylbenzene-steam feed therewith | LUMMUS CREST, INC. (US) | 1986-12-09 | — | — | US | disclosed |
| US-4540832-A | Process for the preparation of 6-chloro-2,4-dinitrophenol | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-09-10 | — | — | US | disclosed |
| EP-0124084-A2 | Process for the preparation of 6-chloro-2,4-dinitrophenol | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-11-07 | — | — | EP | disclosed |
| US-4474646-A | DINITROPHENOIS | THE SHERWIN-WILLIAMS COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| US-4115652-A | Process for the preparation of amino-nitrophenols | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-19 | — | — | US | disclosed |
| US-4089747-A | OXIDATION OF DYE-PROVIDING MATERIALS, A SULFONYL HYDRAZONE AND A COUPLER OR A TRIARYLIMIDAZOLE | EASTMAN KODAK COMPANY (US) | 1978-05-16 | — | — | US | disclosed |
| US-3984405-A | PYRIDO(3,2-B)(1,4)OXAZIN-3(4H)-ONES | E. R. SQUIBB & SONS, INC. (US) | 1976-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035284-A1 | SMALL-MOLECULE INHIBITORS OF DENGUE AND WEST NILE VIRUS PROTEASES | SPINT2, ADAM17, ADAM33 | GPR35 4668/4885TTR 563/4885MAPT 383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.