SCHEMBL1670233

SCHEMBL1670233

Brc1ccc(I)cc1Cc1ccc2c(c1)OCCO2

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 6/20 0.42
HTR1A P08908 1/20 0.39
SLC6A4 P31645 1/20 0.39
POLB P06746 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
HTT P42858 1/20 0.39
BLM P54132 1/20 0.39
SLC5A1 P13866 2/20 0.38
CYP2D6 P10635 1/20 0.38
TERT O14746 1/20 0.38
PDCD1 Q15116 1/20 0.38
CD274 Q9NZQ7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1672720 0.82 SLC5A2 (0.38) SLC5A2HTR1ASLC6A4POLBSLC5A1
SCHEMBL12806098 0.82 CYP2D6 (0.38) SLC5A2SLC6A4SLC5A1CYP2D6TERT
SCHEMBL16560455 0.82 SLC5A2 (0.53) SLC5A2SLC5A1
SCHEMBL1670204 0.81 ALDH1A1 (0.43) SLC5A2POLBMAPT
SCHEMBL28570770 0.81 SLC5A1 (0.53) SLC5A2SLC5A1
SCHEMBL1670175 0.75 CYP2D6 (0.39) MAPTCYP2D6
SCHEMBL10341 0.73 LMNA (0.48) POLBLMNAMAPTHTTBLM
SCHEMBL29413018 0.73 LMNA (0.48) POLBLMNAMAPTHTTBLM
SCHEMBL13470507 0.72 SNCA (0.67) HTR1AMAPTCYP2D6
SCHEMBL13278770 0.72 SLC5A2 (0.64) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE49080-E1 Glycoside derivatives and uses thereof NOVARTIS AG (CH) 2022-05-24 US disclosed
CN-108203432-B Glucopyranosyl derivative and application thereof in medicine 宜昌东阳光长江药业股份有限公司 2021-03-02 CN disclosed
EP-3056507-B1 C-ARYL GLUCOSIDE DERIVATIVE, PREPARATION METHOD FOR SAME, AND MEDICAL APPLICATIONS THEREOF YOUNGENE THERAPEUTICS CO LTD (CN) 2020-09-23 EP disclosed
EP-3056507-B1 C-ARYL GLUCOSIDE DERIVATIVE, PREPARATION METHOD FOR SAME, AND MEDICAL APPLICATIONS THEREOF YOUNGENE THERAPEUTICS CO LTD (CN) 2020-09-23 EP disclosed
US-10011627-B2 C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof YOUNGENE THERAPEUTICS CO., LTD (CN) 2018-07-03 US disclosed
US-10011627-B2 C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof YOUNGENE THERAPEUTICS CO., LTD (CN) 2018-07-03 US disclosed
US-9895389-B2 Glycoside derivatives and uses thereof NOVARTIS AG (CH) 2018-02-20 US disclosed
US-9895389-B2 Glycoside derivatives and uses thereof NOVARTIS AG (CH) 2018-02-20 US disclosed
US-20170042925-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2017-02-16 US disclosed
US-20170042925-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2017-02-16 US disclosed
US-20120178680-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2012-07-12 US disclosed
US-20120178680-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2012-07-12 US disclosed
US-20120178680-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2012-07-12 US disclosed
US-8163704-B2 Glycoside derivatives and uses thereof NOVARTIS AG (CH) 2012-04-24 US disclosed
US-8163704-B2 Glycoside derivatives and uses thereof NOVARTIS AG (CH) 2012-04-24 US disclosed
US-8163704-B2 Glycoside derivatives and uses thereof NOVARTIS AG (CH) 2012-04-24 US disclosed
US-20110171159-A1 Glycoside Derivatives and Uses Thereof NOVARTIS AG (CH) 2011-07-14 US disclosed
US-20110171159-A1 Glycoside Derivatives and Uses Thereof NOVARTIS AG (CH) 2011-07-14 US disclosed
US-20110171159-A1 Glycoside Derivatives and Uses Thereof NOVARTIS AG (CH) 2011-07-14 US disclosed
WO-2011048112-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2011-04-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170042925-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885HTR1A 3802/4885SLC6A4 126/4885
US-20120178680-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885HTR1A 3802/4885SLC6A4 126/4885
US-10011627-B2 C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof SLC5A1, SLC5A2, UGGT1 SLC5A2 2/4885HTR1A 1295/4885SLC6A4 65/4885
US-20110171159-A1 Glycoside Derivatives and Uses Thereof SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885HTR1A 3802/4885SLC6A4 126/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.