Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1051817 | 1.00 | POLB (0.50) | POLBNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL22610059 | 0.90 | NR4A2 (0.47) | POLBNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL16703153 | 0.88 | LMNA (0.44) | POLBNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL4726535 | 0.88 | FFAR1 (0.46) | POLBNPC1RAB9ATDP1L3MBTL1 | |
| SCHEMBL17451407 | 0.85 | FFAR1 (0.42) | SMN1; SMN2L3MBTL1KDM4EFFAR1NR4A2 | |
| SCHEMBL3229701 | 0.80 | POLB (0.75) | POLBNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL4779408 | 0.80 | FFAR1 (0.48) | POLBNPC1RAB9ATDP1L3MBTL1 | |
| SCHEMBL27555763 | 0.80 | TDP1 (0.56) | POLBNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL4725923 | 0.78 | NR4A2 (0.57) | NPC1RAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL14967365 | 0.77 | NR4A2 (0.73) | POLBNPC1RAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015068142-A2 | COMPOSITIONS, PROCESS OF PREPARATION OF SAID COMPOSITIONS, USES AND METHOD OF MANAGEMENT OF MYELOPROLIFERATIVE DISORDER | CELLWORKS GROUP, INC. (US) | 2015-05-14 | — | — | WO | disclosed |