SCHEMBL16703371

SCHEMBL16703371

Nc1nc(N)c(C2CCCCCC2)c(-c2ccncc2)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 3/20 0.45
MAPK13 O15264 2/20 0.45
MAPK9 P45984 2/20 0.45
MAPK12 P53778 2/20 0.45
MAPK11 Q15759 2/20 0.45
MAPK14 Q16539 2/20 0.45
CYP2C19 P33261 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
ADORA2A P29274 3/20 0.40
ADORA1 P30542 3/20 0.40
S1PR1 P21453 1/20 0.39
CDC7 O00311 1/20 0.36
GAA P10253 3/20 0.36
ALDH1A1 P00352 1/20 0.36
ALOX5 P09917 1/20 0.36
HTT P42858 2/20 0.35
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28152086 0.86 DHFR (0.47) CYP1A2CYP3A4CYP2D6CYP2C9ADORA2A
SCHEMBL16701358 0.83 HEXA (0.43) RAF1MAPK13MAPK9MAPK12MAPK11
SCHEMBL28152025 0.78 HRH3 (0.53) CYP2D6ADORA2AADORA1ALDH1A1
SCHEMBL28267193 0.75 HRH3 (0.53) CYP2D6ADORA2AADORA1ALDH1A1
SCHEMBL16701338 0.75 HEXA (0.46) ADORA2AADORA1
SCHEMBL24117519 0.73 CYP2C19 (0.43) RAF1MAPK13MAPK9MAPK12MAPK11
SCHEMBL24117551 0.73 CYP2C19 (0.43) RAF1MAPK13MAPK9MAPK12MAPK11
SCHEMBL24117529 0.73 CYP2C19 (0.43) RAF1MAPK13MAPK9MAPK12MAPK11
SCHEMBL24117520 0.73 CYP2C19 (0.43) RAF1MAPK13MAPK9MAPK12MAPK11
SCHEMBL28151079 0.72 ADORA1 (0.52) CYP2D6ADORA2AADORA1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015069752-A9 ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-07-09 WO disclosed
WO-2015069752-A1 ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-05-14 WO disclosed