Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.66 |
| ▸ | BRD2 | P25440 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8488339 | 0.89 | BRD4 (0.55) | BRD4BRD2TP53NPC1RAB9A | |
| SCHEMBL16845182 | 0.87 | BRD4 (0.56) | BRD4BRD2TP53NPC1RAB9A | |
| SCHEMBL16845109 | 0.84 | BRD4 (0.55) | BRD4BRD2TP53NPC1RAB9A | |
| SCHEMBL14098961 | 0.78 | RAB9A (0.61) | BRD4BRD2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12800383 | 0.75 | BRD4 (0.51) | BRD4BRD2TP53NPC1RAB9A | |
| SCHEMBL1672738 | 0.75 | BRD4 (0.51) | BRD4BRD2TP53NPC1RAB9A | |
| SCHEMBL1672733 | 0.75 | BRD4 (0.51) | BRD4BRD2TP53NPC1RAB9A | |
| SCHEMBL6935548 | 0.74 | ALDH1A1 (0.65) | TP53NPC1RAB9ASMN1; SMN2ALOX15 | |
| SCHEMBL7242479 | 0.73 | TP53 (0.69) | TP53NPC1RAB9ASMN1; SMN2ALOX15 | |
| SCHEMBL16823776 | 0.73 | HTT (0.46) | BRD4BRD2SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |