Sugi Predict

Sugi Predict / Compounds / SCHEMBL1670496

SCHEMBL1670496

SCHEMBL1670496

COc1ccc(C(=O)CCC2OCCCO2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.53
▸ PDE4B Q07343 1/20 0.51
▸ KMT2A Q03164 3/20 0.51
▸ MEN1 O00255 1/20 0.51
▸ ALDH1A1 P00352 1/20 0.51
▸ LMNA P02545 1/20 0.51
▸ POLB P06746 1/20 0.51
▸ HTT P42858 1/20 0.51
▸ HPGD P15428 2/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ L3MBTL1 Q9Y468 1/20 0.50
▸ NPC1 O15118 1/20 0.50
▸ RAB9A P51151 1/20 0.50
▸ MMP1 P03956 1/20 0.50
▸ GSK3B P49841 1/20 0.49
▸ HDAC3 O15379 1/20 0.49
▸ HDAC4 P56524 1/20 0.49
▸ HDAC1 Q13547 1/20 0.49
▸ HDAC7 Q8WUI4 1/20 0.49
▸ HDAC2 Q92769 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7278078 0.94 MAPT (0.55) MAPTPDE4BKMT2AMEN1ALDH1A1
SCHEMBL6285905 0.85 MAPT (0.49) MAPTPDE4BKMT2AMEN1ALDH1A1
SCHEMBL21747300 0.83 CTNNB1 (0.58) MAPTALDH1A1LMNAPOLBHTT
SCHEMBL21747253 0.83 NPC1 (0.55) KMT2AMEN1ALDH1A1LMNAPOLB
SCHEMBL3215720 0.80 RAB9A (0.53) KMT2AMEN1ALDH1A1POLBHTT
SCHEMBL21747244 0.80 KMT2A (0.50) MAPTKMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL3390902 0.80 ALDH1A1 (0.49) MAPTKMT2AMEN1ALDH1A1LMNA
SCHEMBL2207700 0.80 KDM4E (0.51) MAPTKMT2AMEN1ALDH1A1LMNA
SCHEMBL13486215 0.79 NPC1 (0.46) PDE4BALDH1A1LMNAHTTHPGD
SCHEMBL1304895 0.78 ALDH1A1 (0.56) MAPTPDE4BKMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11970495-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2024-04-30 — — US disclosed
US-11945817-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2024-04-02 — — US disclosed
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-17 — — US disclosed
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2023-08-03 — — US disclosed
US-11655249-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2023-05-23 — — US disclosed
EP-3613742-B1 INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE KIND PHARMACEUTICAL (CN) 2022-12-07 — — EP disclosed
US-20210253570-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2021-08-19 — — US disclosed
CN-113004271-A Indolizine derivative and application thereof in medicine 杭州安道药业有限公司 2021-06-22 — — CN disclosed
US-11021478-B2 Indolizine derivatives and their application in medicine KIND PHARMACEUTICAL (CN) 2021-06-01 — — US disclosed
CN-108484598-B Indolizine derivative and application thereof in medicine 杭州安道药业有限公司 2021-03-02 — — CN disclosed
US-20200165242-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE KIND PHARMACEUTICAL (CN) 2020-05-28 — — US disclosed
EP-3613742-A1 INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE Kind Pharmaceutical (CN) 2020-02-26 — — EP disclosed
WO-2011042477-A1 SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS KARO BIO AB (SE) 2011-04-14 — — WO disclosed
WO-2011042477-A1 SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS KARO BIO AB (SE) 2011-04-14 — — WO disclosed
US-6911468-B2 Tyrosine phosphatase inhibitors TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2005-06-28 — — US disclosed
US-20030144338-A1 Tyrosine phosphatase inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2003-07-31 — — US disclosed
EP-1284260-A1 TYROSINE PHOSPHATASE INHIBITORS Takeda Chemical Industries, Ltd. (JP) 2003-02-19 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030144338-A1 Tyrosine phosphatase inhibitors PTPRC, PTPN1, PTPRM MAPT 4800/4885PDE4B 2748/4885KMT2A 629/4885
US-20230257379-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 MAPT 143/4885PDE4B 1611/4885KMT2A 2472/4885
US-11021478-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 MAPT 143/4885PDE4B 1611/4885KMT2A 2472/4885
US-11970495-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 MAPT 143/4885PDE4B 1611/4885KMT2A 2472/4885
US-20230242527-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 MAPT 143/4885PDE4B 1611/4885KMT2A 2472/4885
US-11945817-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 MAPT 143/4885PDE4B 1611/4885KMT2A 2472/4885
US-20210253570-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 MAPT 143/4885PDE4B 1611/4885KMT2A 2472/4885
US-11655249-B2 Indolizine derivatives and their application in medicine INMT, IDO1, IDO2 MAPT 143/4885PDE4B 1611/4885KMT2A 2472/4885
US-20200165242-A1 INDOLIZINE DERIVATIVES AND THEIR APPLICATION IN MEDICINE INMT, IDO1, IDO2 MAPT 143/4885PDE4B 1611/4885KMT2A 2472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.