Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9926878 | 0.96 | GPR84 (0.35) | ABL1ABCB1BCRGPR84BACE1 | |
| SCHEMBL15028784 | 0.95 | ESR1 (0.36) | ESR1ABL1ABCB1BCRGPR84 | |
| SCHEMBL9926882 | 0.94 | ESR1 (0.37) | ESR1ABL1ABCB1BCRGPR84 | |
| SCHEMBL9899249 | 0.91 | ACP1 (0.33) | ABL1ABCB1BCRGPR84PDK2 | |
| SCHEMBL26512580 | 0.91 | ACACA (0.36) | GPR84PDK2MAPTMEN1KMT2A | |
| SCHEMBL25607194 | 0.90 | KDM4E (0.33) | ABL1ABCB1BCRGPR84BACE1 | |
| SCHEMBL9899115 | 0.90 | KDM4E (0.34) | ABL1ABCB1BCRGPR84BACE1 | |
| SCHEMBL1187759 | 0.90 | MAPT (0.33) | ESR1ABL1ABCB1BCRMAPT | |
| SCHEMBL25844182 | 0.90 | GPR84 (0.34) | GPR84MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL25844185 | 0.90 | GPR84 (0.34) | GPR84MAPTMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9028728-B2 | Photochromic materials that include indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2015-05-12 | — | — | US | disclosed |