Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9926882 | 0.99 | ESR1 (0.37) | ESR1PDE4DABL1ABCB1BCR | |
| SCHEMBL9899115 | 0.96 | KDM4E (0.34) | ABL1ABCB1BCRBACE1PDK2 | |
| SCHEMBL16705204 | 0.95 | ESR1 (0.36) | ESR1PDE4DABL1ABCB1BCR | |
| SCHEMBL25607194 | 0.92 | KDM4E (0.33) | ABL1ABCB1BCRBACE1PDK2 | |
| SCHEMBL9898547 | 0.91 | MEN1 (0.34) | ABL1ABCB1BCRBACE1PDK2 | |
| SCHEMBL9926878 | 0.90 | GPR84 (0.35) | ABL1ABCB1BCRBACE1PDK2 | |
| SCHEMBL18102227 | 0.90 | ALDH1A1 (0.35) | ESR1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL16705198 | 0.90 | CYP17A1 (0.34) | PDE4DBACE1KMT2A | |
| SCHEMBL1187759 | 0.90 | MAPT (0.33) | ESR1PDE4DABL1ABCB1BCR | |
| SCHEMBL9926894 | 0.89 | PDK2 (0.37) | BACE1PDK2PTPN1GPR84MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071401-B1 | METHOD OF FORMING A PHOTOCHROMIC SEGMENTED MULTIFOCAL LENS | TRANSITIONS OPTICAL INC (US) | 2017-09-20 | — | — | EP | disclosed |
| US-20160279886-A1 | METHOD OF FORMING A PHOTOCHROMIC SEGMENTED MULTIFOCAL LENS | TRANSITIONS OPTICAL, INC. | 2016-09-29 | — | — | US | disclosed |
| US-9028728-B2 | Photochromic materials that include indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| WO-2013086248-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 2013-06-13 | — | — | WO | disclosed |