Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13554346 | 0.78 | CSF1R (0.41) | PIK3CAPIK3CDPIP5K1CPIK3CBPI4KA | |
| SCHEMBL24091982 | 0.77 | NOS1 (0.43) | CYP1A2KMT2APARP1CYP2A6NOS3 | |
| SCHEMBL13458729 | 0.77 | CCR1 (0.50) | CYP1A2KMT2APIK3CAHPGDSTUBB4A | |
| SCHEMBL31159648 | 0.75 | KMT2A (0.42) | CYP1A2KMT2AHPGDSTUBB4ATUBB | |
| SCHEMBL14044798 | 0.75 | PARP1 (0.36) | CYP1A2KMT2APARP1PTGS2CYP2A6 | |
| SCHEMBL30449077 | 0.74 | MAOB (0.54) | HPGDS | |
| SCHEMBL19808389 | 0.74 | CYP1A2 (0.46) | CYP1A2KMT2ACYP2A6PDE10AMTNR1A | |
| SCHEMBL91410 | 0.74 | KDM1A (0.44) | KMT2ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12416701 | 0.72 | CYP1A2 (0.40) | CYP1A2KMT2APIK3CAHPGDSTUBB4A | |
| SCHEMBL17919945 | 0.72 | CYP1A2 (0.48) | CYP1A2CYP2A6PDE10ALOXLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346830-B1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | disclosed |