Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.43 |
| ▸ | NOS3 | P29474 | 3/20 | 0.43 |
| ▸ | NOS2 | P35228 | 3/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | NCK1 | P16333 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254225 | 0.81 | MCHR1 (0.35) | NOS1NOS2NCF1ALDH1A1KMT2A | |
| SCHEMBL16705355 | 0.77 | CYP1A2 (0.40) | NOS1NOS3NOS2PARP1CYP1A2 | |
| SCHEMBL14044798 | 0.76 | PARP1 (0.36) | NOS1NOS3NOS2PARP1NPC1 | |
| SCHEMBL5355204 | 0.75 | PLAU (0.47) | NOS2RAB9ANCF1MEN1ALDH1A1 | |
| SCHEMBL4556186 | 0.73 | PARP1 (0.38) | PARP1NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL10077023 | 0.73 | PARP1 (0.49) | NOS1NOS3NOS2PARP1CYP1A2 | |
| SCHEMBL20042363 | 0.72 | PARP1 (0.56) | NOS1NOS3NOS2PARP1NPC1 | |
| SCHEMBL20588279 | 0.72 | MAOB (0.49) | NPC1RAB9ASMN1; SMN2CYP1A2MEN1 | |
| SCHEMBL30473687 | 0.72 | BACE1 (0.50) | NOS1NOS2SMN1; SMN2NCF1MEN1 | |
| SCHEMBL4819657 | 0.72 | BACE1 (0.50) | NOS1NOS2SMN1; SMN2NCF1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11198699-B2 | Compounds targeting PRMT5 | ALIGOS THERAPEUTICS, INC. (US) | 2021-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11198699-B2 | Compounds targeting PRMT5 | PRMT5, PRMT1, PRMT6 | NOS1 1113/4885NOS3 1631/4885NOS2 1181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.