Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | NSD3 | Q9BZ95 | 3/20 | 0.36 |
| ▸ | C1R | P00736 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16705385 | 0.84 | CDK8 (0.49) | FERMT2GAKCCNCCDK8ACVR1 | |
| SCHEMBL18544879 | 0.79 | GAK (0.44) | GAKCCNCCDK8NR4A2SOS2 | |
| Iodide SCHEMBL11565912 | 0.78 | GAK (0.43) | GAKCCNCCDK8NR4A2SOS2 | |
| SCHEMBL24338479 | 0.77 | FERMT2 (0.50) | FERMT2GAKGRM4CCNCCDK8 | |
| SCHEMBL30149344 | 0.77 | FERMT2 (0.50) | FERMT2GAKGRM4CCNCCDK8 | |
| SCHEMBL20427414 | 0.76 | HTR1A (0.54) | NSD3C1RNR4A2SOS2KDM4E | |
| SCHEMBL365024 | 0.76 | NR4A2 (0.61) | FERMT2NR4A2SOS2KDM4E | |
| SCHEMBL856135 | 0.76 | FERMT2 (0.49) | FERMT2GAKGRM4CCNCCDK8 | |
| SCHEMBL4619603 | 0.76 | FERMT2 (0.49) | FERMT2GAKGRM4CCNCCDK8 | |
| SCHEMBL16010398 | 0.76 | FERMT2 (0.49) | FERMT2GAKGRM4CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549875-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | disclosed |