SCHEMBL856135

SCHEMBL856135

Fc1ccc2c(Cl)ccnc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FERMT2 Q96AC1 1/20 0.49
NR4A2 P43354 1/20 0.43
SOS2 Q07890 1/20 0.43
GAK O14976 1/20 0.42
GRM4 Q14833 1/20 0.41
AAK1 Q2M2I8 3/20 0.40
CYP1A2 P05177 1/20 0.39
GRM5 P41594 4/20 0.38
MAPT P10636 2/20 0.38
KMT2A Q03164 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
MEN1 O00255 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CCNC P24863 1/20 0.38
CDK8 P49336 1/20 0.38
IDO1 P14902 1/20 0.38
ACVR1 Q04771 1/20 0.37
CLK4 Q9HAZ1 1/20 0.37
AXL P30530 1/20 0.37
PRKCI P41743 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29691695 0.84 CCNC (0.49) FERMT2NR4A2GAKAAK1CYP1A2
SCHEMBL265444 0.84 CCNC (0.49) FERMT2NR4A2GAKAAK1CYP1A2
SCHEMBL317202 0.79 NR4A2 (0.66) FERMT2NR4A2SOS2CYP1A2MAPT
SCHEMBL29396540 0.79 NR4A2 (0.66) FERMT2NR4A2SOS2CYP1A2MAPT
Bromide SCHEMBL1611915 0.78 NR4A2 (0.63) FERMT2NR4A2SOS2CYP1A2MAPT
SCHEMBL4655567 0.78 AXL (0.42) FERMT2NR4A2SOS2CYP1A2MAPT
Bromide SCHEMBL1611919 0.78 NR4A2 (0.63) FERMT2NR4A2SOS2CYP1A2MAPT
Hydrochloric Acid SCHEMBL11519956 0.78 NR4A2 (0.63) FERMT2NR4A2SOS2CYP1A2MAPT
SCHEMBL4619603 0.76 FERMT2 (0.49) FERMT2GAKGRM4AAK1L3MBTL1
SCHEMBL16010398 0.76 FERMT2 (0.49) FERMT2NR4A2SOS2GAKGRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119241502-B NSD3 degradation agent and preparation method and application thereof 四川大学华西医院 2025-02-28 CN claimed
CN-119241502-A NSD3 degradation agent and preparation method and application thereof 四川大学华西医院 2025-01-03 CN claimed
US-12612384-B2 Heterocyclic CYP4A inhibitor compounds and compositions thereof MBD Co., Ltd. (KR) 2026-04-28 US disclosed
US-12522595-B2 Bicyclic ether O-glycoprotein-2-acetamido-2-deoxy-3-D-glucopyranosidase inhibitors BIOGEN MA INC. (US) 2026-01-13 US disclosed
US-12479821-B2 Quinoline compound and use thereof MBD Co., Ltd. (KR) 2025-11-25 US disclosed
CN-119241502-B NSD3 degradation agent and preparation method and application thereof 四川大学华西医院 2025-02-28 CN disclosed
US-20250059157-A1 TLR7/8 ANTAGONISTS AND USES THEREOF MERCK PATENT GMBH (DE) 2025-02-20 US disclosed
CN-119241502-A NSD3 degradation agent and preparation method and application thereof 四川大学华西医院 2025-01-03 CN disclosed
US-20240360131-A1 BIARYL KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2024-10-31 US disclosed
US-20240287032-A1 NOVEL HETEROCYCLIC COMPOUND AND USE THEREOF MBD Co., Ltd. (KR) 2024-08-29 US disclosed
US-12065437-B2 Biaryl kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2024-08-20 US disclosed
EP-1534681-A1 SUBSTITUTED QUINOLINE CCR5 RECEPTOR ANTAGONISTS SCHERING AKTIENGESELLSCHAFT (DE) 2005-06-01 EP disclosed
US-20040132769-A1 Certain phenylacetic acids and derivatives NOVARTIS AG (CH) 2004-07-08 US disclosed
WO-2004048314-A1 SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS NOVARTIS AG (CH) 2004-06-10 WO disclosed
US-20040072818-A1 Substituted quinoline CCR5 receptor antagonists SCHERING AKTIENGESELLSCHAFT (DE) 2004-04-15 US disclosed
WO-2004002960-A1 SUBSTITUTED QUINOLINE CCR5 RECEPTOR ANTAGONISTS SCHERING AKTIENGESELLSCHAFT (DE) 2004-01-08 WO disclosed
EP-0326331-B1 Substituted quinolines and cinnolines DOW AGROSCIENCES LLC (US) 2002-04-17 EP disclosed
US-5294622-A Fungicides, insecticides, miticides DOWELANCO (US) 1994-03-15 US disclosed
US-5114939-A Amine or ether substitutes compounds of quinoline or cinnoline DOWELANCO (US) 1992-05-19 US disclosed
EP-0326331-A2 Substituted quinolines and cinnolines DowElanco (US) 1989-08-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240287032-A1 NOVEL HETEROCYCLIC COMPOUND AND USE THEREOF CYP4B1, CYP4A11, CYP3A4 FERMT2 3657/4885NR4A2 91/4885SOS2 4144/4885
US-12479821-B2 Quinoline compound and use thereof CYP4A11, CYP7A1, CYP4B1 FERMT2 1658/4885NR4A2 132/4885SOS2 3523/4885
US-12612384-B2 Heterocyclic CYP4A inhibitor compounds and compositions thereof CYP4A11, CYP4B1, CYP4A22 FERMT2 4024/4885NR4A2 117/4885SOS2 2348/4885
US-20040132769-A1 Certain phenylacetic acids and derivatives CYP2A6, HCAR2, CYP2B6 FERMT2 4349/4885NR4A2 795/4885SOS2 4388/4885
US-12065437-B2 Biaryl kinase inhibitors AAK1, NCK1, MARCKS FERMT2 2067/4885NR4A2 2752/4885SOS2 1408/4885
US-20250059157-A1 TLR7/8 ANTAGONISTS AND USES THEREOF TLR7, TLR8, TLR9 FERMT2 3334/4885NR4A2 70/4885SOS2 3266/4885
US-20040072818-A1 Substituted quinoline CCR5 receptor antagonists CCR5, CXCR3, CCR2 FERMT2 3714/4885NR4A2 299/4885SOS2 1911/4885
US-20240360131-A1 BIARYL KINASE INHIBITORS AAK1, NCK1, MARCKS FERMT2 2067/4885NR4A2 2752/4885SOS2 1408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.