Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.61 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.61 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | NSD3 | Q9BZ95 | 3/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3854038 | 1.00 | NR4A2 (0.61) | NR4A2SOS2NCF1FERMT2GAK | |
| SCHEMBL16446547 | 0.84 | NR4A2 (0.61) | NR4A2SOS2NCF1FERMT2GAK | |
| SCHEMBL3073397 | 0.79 | NR4A2 (0.66) | NR4A2SOS2NCF1ALDH1A1ACHE | |
| SCHEMBL30044428 | 0.79 | NR4A2 (0.66) | NR4A2SOS2NCF1ALDH1A1ACHE | |
| SCHEMBL6660966 | 0.77 | GRM4 (0.56) | FERMT2GAKGRM4NSD3NSD2 | |
| SCHEMBL596040 | 0.76 | NR4A2 (1.00) | NR4A2SOS2NCF1FERMT2ALDH1A1 | |
| SCHEMBL16705392 | 0.76 | FERMT2 (0.49) | NR4A2SOS2FERMT2GAKGRM4 | |
| SCHEMBL4619603 | 0.76 | FERMT2 (0.49) | FERMT2GAKGRM4CCNCCDK8 | |
| SCHEMBL3319590 | 0.76 | NR4A2 (0.61) | NR4A2SOS2NCF1FERMT2GAK | |
| SCHEMBL3071029 | 0.76 | NR4A2 (0.61) | NR4A2SOS2NCF1ALDH1A1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086751-A1 | SWEETENER COMPOSITION | SENOMYX, INC. | 2018-03-29 | — | — | US | disclosed |
| US-9902737-B2 | Sweet flavor modifier | SENOMYX, INC. (US) | 2018-02-27 | — | — | US | disclosed |
| US-20160251372-A1 | SWEET FLAVOR MODIFIER | FIRMENICH INCORPORATED | 2016-09-01 | — | — | US | disclosed |
| US-20150265711-A1 | SWEET FLAVOR MODIFIER | FIRMENICH INCORPORATED | 2015-09-24 | — | — | US | disclosed |
| US-20150245642-A1 | METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER | FIRMENICH INCORPORATED | 2015-09-03 | — | — | US | disclosed |
| US-9049878-B2 | Sweet flavor modifier | SENOMYX, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-9000054-B2 | Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer | SENOMYX, INC. (US) | 2015-04-07 | — | — | US | disclosed |
| US-20140128481-A1 | SWEET FLAVOR MODIFIER | SENOMYX, INC. (US) | 2014-05-08 | — | — | US | disclosed |
| EP-2603098-A2 | METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER | Senomyx, Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| US-20120041078-A1 | METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER | SENOMYX, INC. (US) | 2012-02-16 | — | — | US | disclosed |
| WO-2012021837-A2 | METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER | SENOMYX, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
| US-20110245353-A1 | SWEET FLAVOR MODIFIER | SENOMYS, INC. (US) | 2011-10-06 | — | — | US | disclosed |
| EP-1567477-B1 | SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS | NOVARTIS AG (CH) | 2009-09-09 | — | — | EP | disclosed |
| US-7202364-B2 | Certain phenylacetic acids and derivatives | NOVARTIS, AG (CH) | 2007-04-10 | — | — | US | disclosed |
| EP-1567477-A1 | SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS | Novartis AG (CH) | 2005-08-31 | — | — | EP | disclosed |
| US-20040132769-A1 | Certain phenylacetic acids and derivatives | NOVARTIS AG (CH) | 2004-07-08 | — | — | US | disclosed |
| WO-2004048314-A1 | SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS | NOVARTIS AG (CH) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041078-A1 | METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER | TFEB, TREH, SLC2A8 | NR4A2 2211/4885SOS2 868/4885NCF1 2070/4885 |
| US-20150245642-A1 | METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER | TFEB, TREH, SLC2A8 | NR4A2 2211/4885SOS2 868/4885NCF1 2070/4885 |
| US-20110245353-A1 | SWEET FLAVOR MODIFIER | TAS2R5, TAS2R10, TAS2R50 | NR4A2 3067/4885SOS2 3976/4885NCF1 2295/4885 |
| US-20040132769-A1 | Certain phenylacetic acids and derivatives | CYP2A6, HCAR2, CYP2B6 | NR4A2 795/4885SOS2 4388/4885NCF1 2304/4885 |
| US-20150265711-A1 | SWEET FLAVOR MODIFIER | TAS2R5, TAS2R10, TAS2R50 | NR4A2 3067/4885SOS2 3976/4885NCF1 2295/4885 |
| US-20180086751-A1 | SWEETENER COMPOSITION | TAS2R50, TAS1R2, TAS2R10 | NR4A2 3230/4885SOS2 1367/4885NCF1 3002/4885 |
| US-20140128481-A1 | SWEET FLAVOR MODIFIER | TAS2R5, TAS2R10, TAS2R50 | NR4A2 3067/4885SOS2 3976/4885NCF1 2295/4885 |
| US-20160251372-A1 | SWEET FLAVOR MODIFIER | TAS2R5, TAS2R10, TAS2R50 | NR4A2 3067/4885SOS2 3976/4885NCF1 2295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.