Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 7/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | GPR6 | P46095 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1874103 | 0.87 | SCN10A (0.40) | SCN10ASYKMALT1CNR2 | |
| Trifluoroacetic Acid SCHEMBL1669806 | 0.79 | AR (0.43) | HRH4HRH3GPR6MALT1LNPEP | |
| Trifluoroacetic Acid SCHEMBL1669971 | 0.74 | LNPEP (0.42) | HRH4HRH3GPR6MALT1LNPEP | |
| Trifluoroacetic Acid SCHEMBL1670534 | 0.73 | CCR1 (0.38) | SCN10AHRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL1873566 | 0.71 | LOXL2 (0.45) | SCN10AHRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL2712250 | 0.71 | MAPK1 (0.46) | HRH4HRH3SYKMALT1 | |
| SCHEMBL1098419 | 0.69 | KDM4E (0.49) | — | |
| SCHEMBL30001546 | 0.68 | SCN10A (0.44) | SCN10A | |
| SCHEMBL12049703 | 0.67 | SCN10A (0.44) | SCN10ASYK | |
| Hydrochloric Acid SCHEMBL27827199 | 0.67 | SYK (0.39) | SCN10ASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491028-A1 | INDAZOLE AND PYRAZOLOPYRIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011049917-A1 | INDAZOLE AND PYRAZOLOPYRIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-04-28 | — | — | WO | disclosed |