Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31313149 | 0.87 | L3MBTL1 (0.35) | NAMPTKDM5BACHEL3MBTL1IDH1 | |
| SCHEMBL4612816 | 0.80 | ACHE (0.49) | NAMPTKDM5BPRMT5WDR77SYK | |
| SCHEMBL2735687 | 0.78 | NAMPT (0.42) | NAMPTKDM5BPRMT5WDR77SYK | |
| SCHEMBL10100353 | 0.78 | NAMPT (0.42) | NAMPTKDM5BPRMT5WDR77SYK | |
| SCHEMBL671590 | 0.78 | — | — | |
| SCHEMBL1703139 | 0.77 | MAPT (0.41) | NAMPTKDM5BPRMT5WDR77SYK | |
| SCHEMBL19122813 | 0.77 | NAMPT (0.41) | NAMPTKDM5BPRMT5WDR77SYK | |
| SCHEMBL16100862 | 0.77 | NAMPT (0.44) | NAMPTKDM5BPRMT5WDR77SYK | |
| SCHEMBL14077265 | 0.77 | NAMPT (0.41) | NAMPTKDM5BPRMT5WDR77SYK | |
| SCHEMBL24973097 | 0.76 | NAMPT (0.40) | NAMPTKDM5BPRMT5WDR77SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549875-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | disclosed |