⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078516 | 1.00 | — | — | |
| SCHEMBL9327903 | 1.00 | — | — | |
| SCHEMBL16784061 | 0.93 | ALDH1A1 (0.48) | — | |
| SCHEMBL11806490 | 0.88 | ALDH1A1 (0.41) | — | |
| SCHEMBL9283100 | 0.84 | TDP1 (0.43) | — | |
| SCHEMBL16705750 | 0.81 | ALDH1A1 (0.45) | — | |
| SCHEMBL16705748 | 0.81 | ALDH1A1 (0.63) | — | |
| SCHEMBL8910529 | 0.81 | ALDH1A1 (0.45) | — | |
| SCHEMBL25417540 | 0.79 | TDP1 (0.43) | — | |
| SCHEMBL16689754 | 0.79 | ALDH1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170135962-A1 | NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADEABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | SIRNA THERAPEUTICS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-9402816-B2 | Diester and triester based low molecular weight, biodegradeable cationic lipids for oligonucleotide delivery | SIMA THERAPEUTICS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-9309344-B2 | Process for preparing polymers by means of ring-opening polymerization | EVONIK DEGUSSA GMBH (DE) | 2016-04-12 | — | — | US | disclosed |
| US-20150299362-A1 | PROCESS FOR PREPARING POLYMERS BY MEANS OF RING-OPENING POLYMERIZATION | EVONIK INDUSTRIES AG (DE) | 2015-10-22 | — | — | US | disclosed |
| US-20150133519-A1 | NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADEABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | BANK OF AMERICA, N.A. | 2015-05-14 | — | — | US | disclosed |