Sugi Predict

Sugi Predict / Compounds / SCHEMBL16705773

SCHEMBL16705773

SCHEMBL16705773

CCCCCCC/C=C\CCCCCCCCC(=O)CCCCCCCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SOAT2 O75908 1/20 0.47
▸ SOAT1 P35610 1/20 0.47
▸ FAAH O00519 7/20 0.46
▸ EPHX2 P34913 2/20 0.46
▸ CES1 P23141 2/20 0.44
▸ CNR1 P21554 1/20 0.44
▸ CNR2 P34972 1/20 0.44
▸ ALDH1A1 P00352 4/20 0.43
▸ F7 P08709 3/20 0.43
▸ F3 P13726 3/20 0.43
▸ PPARG P37231 3/20 0.43
▸ PPARA Q07869 3/20 0.43
▸ PPARD Q03181 2/20 0.43
▸ DUSP3 P51452 2/20 0.43
▸ LMNA P02545 2/20 0.43
▸ FABP4 P15090 2/20 0.43
▸ ALOX15 P16050 2/20 0.43
▸ HSD17B10 Q99714 2/20 0.43
▸ PTPN7 P35236 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31528892 0.98 EPHX2 (0.47) SOAT2SOAT1FAAHEPHX2CES1
SCHEMBL31528801 0.98 EPHX2 (0.47) SOAT2SOAT1FAAHEPHX2CES1
SCHEMBL31528860 0.98 EPHX2 (0.47) SOAT2SOAT1FAAHEPHX2CES1
SCHEMBL16705769 0.98 EPHX2 (0.47) SOAT2SOAT1FAAHEPHX2CES1
SCHEMBL29113338 0.93 MAPT (0.41) EPHX2CES1ALDH1A1LMNAHSD17B10
SCHEMBL29689176 0.93 MAPT (0.41) EPHX2CES1ALDH1A1LMNAHSD17B10
SCHEMBL31528836 0.93 MAPT (0.41) EPHX2CES1ALDH1A1LMNAHSD17B10
SCHEMBL16705778 0.92 DGKA (0.41) SOAT2SOAT1FAAHEPHX2CES1
SCHEMBL4341940 0.91 PPARG (0.41) SOAT2SOAT1FAAHEPHX2CES1
SCHEMBL4341938 0.91 PPARG (0.41) SOAT2SOAT1FAAHEPHX2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170135962-A1 NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADEABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY SIRNA THERAPEUTICS, INC. (US) 2017-05-18 — — US disclosed
US-9402816-B2 Diester and triester based low molecular weight, biodegradeable cationic lipids for oligonucleotide delivery SIMA THERAPEUTICS, INC. (US) 2016-08-02 — — US disclosed
US-20150133519-A1 NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADEABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY BANK OF AMERICA, N.A. 2015-05-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150133519-A1 NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADEABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY CYP46A1, CETP, LIPC SOAT2 209/4885SOAT1 123/4885FAAH 1196/4885
US-20170135962-A1 NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADEABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY CYP46A1, CETP, LIPC SOAT2 209/4885SOAT1 123/4885FAAH 1196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.