Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29113338 | 1.00 | MAPT (0.41) | MAPTKMT2AALDH1A1TSHRCES2 | |
| SCHEMBL31528836 | 1.00 | MAPT (0.41) | MAPTKMT2AALDH1A1TSHRCES2 | |
| SCHEMBL31528937 | 0.93 | DGKA (0.44) | ALDH1A1TSHRLMNAKDM4EPOLB | |
| SCHEMBL31528875 | 0.93 | DGKA (0.44) | ALDH1A1TSHRLMNAKDM4EPOLB | |
| SCHEMBL16705773 | 0.93 | SOAT2 (0.47) | MAPTALDH1A1TSHRCES1LMNA | |
| SCHEMBL31528904 | 0.93 | DGKA (0.44) | ALDH1A1TSHRLMNAKDM4EPOLB | |
| SCHEMBL12799225 | 0.92 | CES2 (0.39) | KMT2AALDH1A1TSHRCES2CES1 | |
| SCHEMBL16705772 | 0.92 | PPARG (0.41) | ALDH1A1TSHRCES2CES1LMNA | |
| SCHEMBL31528801 | 0.91 | EPHX2 (0.47) | ALDH1A1TSHRCES1LMNAKDM4E | |
| SCHEMBL31528892 | 0.91 | EPHX2 (0.47) | ALDH1A1TSHRCES1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255888-A2 | LIPID NANOPARTICLE COMPOSITIONS CONTAINING MONOESTER CATIONIC LIPIDS | Merck Sharp & Dohme LLC (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022119883-A2 | LIPID NANOPARTICLE COMPOSITIONS CONTAINING MONOESTER CATIONIC LIPIDS | MERCK SHARP & DOHME CORP. (US) | 2022-06-09 | — | — | WO | disclosed |