Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670320 | 1.00 | ESR1 (0.34) | ESR1TTRHSP90AB1ESR2 | |
| SCHEMBL1671021 | 0.90 | ESR1 (0.34) | ESR1HSP90AB1ESR2 | |
| SCHEMBL1671020 | 0.90 | ESR1 (0.34) | ESR1HSP90AB1ESR2 | |
| SCHEMBL1670917 | 0.89 | TTR (0.38) | ESR1TTRHSP90AB1ESR2 | |
| SCHEMBL12801005 | 0.89 | TTR (0.34) | ESR1TTRHSP90AB1ESR2 | |
| SCHEMBL1670649 | 0.82 | ESR1 (0.35) | ESR1TTRHSP90AB1ESR2 | |
| SCHEMBL1671741 | 0.75 | ERN1 (0.35) | TTR | |
| SCHEMBL1672952 | 0.74 | ESR2 (0.36) | ESR1HSP90AB1ESR2 | |
| SCHEMBL1672953 | 0.74 | ESR2 (0.36) | ESR1HSP90AB1ESR2 | |
| SCHEMBL12800994 | 0.71 | TTR (0.35) | ESR1TTRHSP90AB1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |