Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | WRN | Q14191 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670917 | 0.86 | TTR (0.38) | ERN1TTR | |
| SCHEMBL1671504 | 0.81 | ERN1 (0.36) | ERN1TTRGRM2POLBMAPT | |
| SCHEMBL12801005 | 0.76 | TTR (0.34) | TTR | |
| SCHEMBL1670927 | 0.69 | AMY1A (0.36) | TTRPTGS1PTGS2POLBMAPT | |
| SCHEMBL12800447 | 0.68 | PTGS2 (0.41) | PTGS2POLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1682483 | 0.66 | ERN1 (0.42) | ERN1PTGS1PTGS2GRM2POLB | |
| SCHEMBL20924977 | 0.65 | ERN1 (0.43) | ERN1PTGS1PTGS2GRM2POLB | |
| SCHEMBL20547398 | 0.63 | MAPT (0.39) | POLBMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL1670909 | 0.63 | PTGS2 (0.40) | PTGS2MAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL18490234 | 0.60 | CHRM2 (0.37) | ERN1PTGS2POLBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |