Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14105717 | 0.83 | ALDH1A1 (0.49) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1305579 | 0.81 | POLB (0.59) | GSK3BMAPTKMT2AALDH1A1CES1 | |
| SCHEMBL4609622 | 0.80 | MAPT (0.58) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14105300 | 0.78 | TAS1R3 (0.50) | MAPTKMT2APDE4BALOX15 | |
| SCHEMBL14809467 | 0.77 | ACHE (0.49) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL14105716 | 0.77 | TAS1R3 (0.50) | MAPTKMT2AALDH1A1NPC1CYP1A2 | |
| SCHEMBL19230608 | 0.77 | TYK2 (0.46) | MAPTKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL5895627 | 0.76 | ALDH1A1 (0.49) | MAPTKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL30354750 | 0.76 | F2RL1 (0.60) | KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL17795888 | 0.76 | PDE4A (0.46) | MAPTKMT2ACA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |
| WO-2008097483-A2 | METHODS FOR PREPARING ARYL-SUBSTITUTED KETOPHOSPHONATES | NEUROGEN CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |