Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | USP9X | Q93008 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16712132 | 0.86 | KCNH2 (0.39) | KCNH2CYP2C8CYP2C9ACLYPTGDR | |
| SCHEMBL27769009 | 0.80 | CRHR1 (0.40) | KCNH2CYP2C8CYP2C9ACLYALDH1A1 | |
| SCHEMBL16712122 | 0.73 | PDE2A (0.41) | KCNH2CYP2C8CYP2C9MEN1KMT2A | |
| SCHEMBL22187765 | 0.72 | MAPT (0.42) | KCNH2CYP2C8CYP2C9ACLYALDH1A1 | |
| SCHEMBL21057173 | 0.71 | SLC6A4 (0.47) | CYP2C9ALDH1A1KMT2APPARGPPARA | |
| SCHEMBL21057171 | 0.71 | SLC6A4 (0.47) | CYP2C9ALDH1A1KMT2APPARGPPARA | |
| SCHEMBL23368023 | 0.70 | ALDH1A1 (0.53) | CYP2C9ALDH1A1MAPTKMT2APPARG | |
| SCHEMBL31709885 | 0.70 | KCNH2 (0.49) | KCNH2CYP2C8CYP2C9ACLYALDH1A1 | |
| SCHEMBL7031591 | 0.70 | ALDH1A1 (0.46) | ACLYALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL31710093 | 0.70 | ALDH1A1 (0.55) | ACLYALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527841-B2 | Substituted pyrido[2,3-b]pyrazines as phosphodiesterase 2A inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-27 | — | — | US | disclosed |
| US-20150158863-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-06-11 | — | — | US | disclosed |
| EP-2873669-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158863-A1 | HETEROCYCLIC COMPOUND | PDE2A, PDE5A, PDE3A | KCNH2 845/4885CYP2C8 2246/4885CYP2C9 1512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.