SCHEMBL16712938

SCHEMBL16712938

COc1cccc(-c2cc(C(=O)Cl)ccc2OC(C)=O)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.51
HSP90AA1 P07900 2/20 0.49
HSP90AB1 P08238 2/20 0.49
GAPDH P04406 2/20 0.49
BACE1 P56817 2/20 0.49
HTT P42858 3/20 0.44
ALDH1A1 P00352 3/20 0.44
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
TP53 P04637 1/20 0.44
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
HDAC4 P56524 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
TSHR P16473 1/20 0.43
PARP1 P09874 1/20 0.42
LMNA P02545 2/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18084829 0.92 GAPDH (0.49) SYKHSP90AA1HSP90AB1GAPDHBACE1
SCHEMBL16712928 0.90 HSP90AA1 (0.49) SYKHSP90AA1HSP90AB1GAPDHBACE1
SCHEMBL6934114 0.89 HSP90AA1 (0.58) SYKHSP90AA1HSP90AB1HTTALDH1A1
SCHEMBL18087562 0.83 MAOB (0.53) SYKHSP90AA1HSP90AB1GAPDHBACE1
SCHEMBL28960702 0.82 BACE1 (0.67) SYKGAPDHBACE1HTTALDH1A1
SCHEMBL16712944 0.82 AKR1C3 (0.50) SYKHSP90AA1HSP90AB1GAPDHBACE1
SCHEMBL16713007 0.81 SYK (0.53) SYKHSP90AA1HSP90AB1HTTTP53
SCHEMBL24313994 0.81 HTT (0.56) SYKHSP90AA1HSP90AB1GAPDHBACE1
SCHEMBL18084823 0.80 GAPDH (0.49) SYKHSP90AA1HSP90AB1GAPDHBACE1
SCHEMBL15225947 0.78 HSP90AA1 (0.58) SYKHSP90AA1HSP90AB1HTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3066072-B1 BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS UNIV KANSAS (US) 2021-11-03 EP disclosed
WO-2015070091-A1 BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS THE UNIVERSITY OF KANSAS (US) 2015-05-14 WO disclosed