Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.50 |
| ▸ | GAPDH | P04406 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | CTSA | P10619 | 5/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16710317 | 0.90 | CTSA (0.49) | AKR1C3AKR1C2GAPDHBACE1AKR1C4 | |
| SCHEMBL6934499 | 0.85 | HDAC4 (0.50) | AKR1C3AKR1C2AKR1C4AKR1C1CTSA | |
| SCHEMBL18084777 | 0.84 | AKR1C3 (0.46) | AKR1C3AKR1C2BACE1CTSASYK | |
| SCHEMBL18087562 | 0.83 | MAOB (0.53) | GAPDHBACE1SYKHDAC4HDAC2 | |
| SCHEMBL28960702 | 0.82 | BACE1 (0.67) | GAPDHBACE1SYKHDAC4HDAC2 | |
| SCHEMBL16712938 | 0.82 | SYK (0.51) | GAPDHBACE1SYKHDAC4HDAC2 | |
| SCHEMBL24313994 | 0.81 | HTT (0.56) | GAPDHBACE1SYKHSP90AA1HSP90AB1 | |
| SCHEMBL18084823 | 0.80 | GAPDH (0.49) | GAPDHBACE1CTSASYKHDAC4 | |
| SCHEMBL16712945 | 0.78 | PTPN5 (0.52) | AKR1C3AKR1C2AKR1C4AKR1C1HDAC4 | |
| SCHEMBL16710322 | 0.78 | LMNA (0.50) | AKR1C3AKR1C2AKR1C4AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10689344-B2 | Biphenylamide derivative Hsp90 inhibitors | UNIVERSITY OF KANSAS (US) | 2020-06-23 | — | — | US | disclosed |
| WO-2015070091-A1 | BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS | THE UNIVERSITY OF KANSAS (US) | 2015-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689344-B2 | Biphenylamide derivative Hsp90 inhibitors | HSP90AB1, HSP90AA1, HSP90AB2P | AKR1C3 1964/4885AKR1C2 2289/4885GAPDH 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.