Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.74 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.74 |
| ▸ | PRKACA | P17612 | 2/20 | 0.74 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.74 |
| ▸ | PRKX | P51817 | 2/20 | 0.74 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.74 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.74 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.74 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.74 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.74 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.74 |
| ▸ | PRKCG | P05129 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | AKT1 | P31749 | 1/20 | 0.74 |
| ▸ | GSK3A | P49840 | 1/20 | 0.74 |
| ▸ | GSK3B | P49841 | 1/20 | 0.74 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.74 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.74 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.74 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1569160 | 0.91 | CYP3A4 (0.74) | ROCK2ROCK1PRKACARPS6KB1PRKX | |
| SCHEMBL30828595 | 0.88 | MMP13 (0.88) | ROCK2ROCK1PRKACARPS6KB1PRKX | |
| SCHEMBL8987867 | 0.86 | MEN1 (0.78) | CYP3A4MAPK14TSHRMEN1KMT2A | |
| SCHEMBL1926318 | 0.85 | EPHX2 (0.77) | ROCK2ROCK1PRKACARPS6KB1PRKX | |
| SCHEMBL3812691 | 0.85 | ROCK2 (1.00) | ROCK2ROCK1PRKACARPS6KB1PRKX | |
| SCHEMBL20379630 | 0.82 | NAMPT (0.88) | CYP3A4MAPK14NAMPT | |
| SCHEMBL539269 | 0.82 | MMP13 (1.00) | ROCK2ROCK1PRKACARPS6KB1PRKX | |
| SCHEMBL11626607 | 0.82 | KMT2A (0.74) | ROCK2ROCK1PRKACARPS6KB1PRKX | |
| SCHEMBL14527348 | 0.81 | HDAC1 (0.62) | ROCK2ROCK1PRKACARPS6KB1PRKX | |
| SCHEMBL26101409 | 0.81 | NAMPT (0.81) | MAPK1RAB9ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617214-B2 | Compounds for cognitive enhancement and methods of use thereof | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2017-04-11 | — | — | US | disclosed |
| US-9617214-B2 | Compounds for cognitive enhancement and methods of use thereof | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2017-04-11 | — | — | US | disclosed |
| US-20160272587-A1 | COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-09-22 | — | — | US | disclosed |
| US-20160272587-A1 | COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-09-22 | — | — | US | disclosed |
| WO-2015070170-A1 | COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272587-A1 | COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF | ROCK1, ROCK2, RHOA | ROCK2 2/4885ROCK1 1/4885PRKACA 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.