Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 8/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.45 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12872215 | 0.84 | PDK1 (0.42) | RAPGEF4NOTUMIDO1HTR3EHTR3B | |
| SCHEMBL10251222 | 0.84 | PDK1 (0.42) | RAPGEF4NOTUMIDO1HTR3EHTR3B | |
| SCHEMBL12508243 | 0.84 | AR (0.57) | RAPGEF4NOTUMIDO1HTR3EHTR3B | |
| SCHEMBL18837644 | 0.83 | RAPGEF4 (0.40) | RAPGEF4NOTUMIDO1HTR3EHTR3B | |
| SCHEMBL1043249 | 0.82 | SMN1; SMN2 (0.45) | RAPGEF4NOTUMPDK1MAPTTP53 | |
| SCHEMBL803633 | 0.79 | SMN1; SMN2 (0.44) | RAPGEF4LMNAPDK1MAPTTP53 | |
| SCHEMBL4273522 | 0.78 | SMN1; SMN2 (0.45) | NOTUMSMN1; SMN2 | |
| SCHEMBL14649867 | 0.78 | AR (0.53) | RAPGEF4 | |
| SCHEMBL10030392 | 0.76 | GLA (0.54) | SMN1; SMN2 | |
| SCHEMBL987352 | 0.76 | IDO1 (0.50) | RAPGEF4NOTUMIDO1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 539 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495540-B2 | HEXAHYDROAZEPINE-2-ONE DERIVATIVE AS BETA-AMYLOID INHIBITOR | BRISTOL - MYERS SQUIBB PHARMA COMPANY | 2002-12-17 | — | — | US | claimed |
| US-20020010172-A1 | Lactams as inhibitors of A-beta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-01-24 | — | — | US | claimed |
| EP-4157844-B1 | 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER | CENTRE NAT RECH SCIENT (FR) | 2024-07-10 | — | — | EP | disclosed |
| WO-2024073559-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |
| WO-2024026484-A2 | CDK2 INHIBITORS AND METHODS OF USING THE SAME | CEDILLA THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| WO-2024026481-A2 | CDK2 INHIBITORS AND METHODS OF USING THE SAME | CEDILLA THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| WO-2023237759-A1 | DIHYDRO[1,8]NAPHTHYRIDIN-7-ONE AND PYRIDO[3,2-B][1,4]OXAZIN-3-ONE FOR USE IN TREATING CANCER, AND METASTASES IN PARTICULAR | ANAGENESIS BIOTECHNOLOGIES (FR) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023239768-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | INCYTE CORPORATION (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023230179-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING CANCER | CASE WESTERN RESERVE UNIVERSITY (US) | 2023-11-30 | — | — | WO | disclosed |
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| US-20230374008-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2023-11-23 | — | — | US | disclosed |
| EP-0156278-B1 | PROCESS FOR THE PREPARATION OF SYMMETRICAL BENZOPHENONES SUBSTITUTED BY FLUOR-CONTAINING GROUPS, THEIR USE AND SYMMETRICAL BENZOPHENONES SUBSTITUTED BY FLUOR-CONTAINING GROUPS | BAYER AG (DE) | 1988-03-02 | — | — | EP | disclosed |
| US-4659720-A | POULTRY ANTIPROTOZOA AGENT | MERCK & CO., INC. (US) | 1987-04-21 | — | — | US | disclosed |
| EP-0113570-B1 | 5-(AMINO OR SUBSTITUTED AMINO) IMIDAZOLES | MERCK & CO. INC. (US) | 1987-02-25 | — | — | EP | disclosed |
| EP-0084128-B1 | PROCESS FOR THE PREPARATION OF ALKYLBENZENES SUBSTITUTED BY RADICALS CONTAINING FLUORINE | BAYER AG (DE) | 1987-01-21 | — | — | EP | disclosed |
| EP-0156278-A2 | Process for the preparation of symmetrical benzophenones substituted by fluor-containing groups, their use and symmetrical benzophenones substituted by fluor-containing groups | BAYER AG (DE) | 1985-10-02 | — | — | EP | disclosed |
| EP-0155441-A1 | A process for separating nitration isomers of substituted benzene compounds | Monsanto Company (US) | 1985-09-25 | — | — | EP | disclosed |
| US-4503276-A | Process for separating nitration isomers of substituted benzene compounds | MONSANTO COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0113570-A1 | 5-(Amino or substituted amino) imidazoles | MERCK & CO. INC. (US) | 1984-07-18 | — | — | EP | disclosed |
| EP-0084128-A1 | Process for the preparation of alkylbenzenes substituted by radicals containing fluorine | BAYER AG (DE) | 1983-07-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230374008-A1 | BICYCLIC COMPOUNDS | SLC10A1, PKD1, CYP11B2 | RAPGEF4 3615/4885NOTUM 535/4885IDO1 2754/4885 |
| US-20020010172-A1 | Lactams as inhibitors of A-beta protein production | BACE1, APP, APH1A | RAPGEF4 2254/4885NOTUM 300/4885IDO1 2498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.